TY - T1的纵向的儿童临床肺间隙指数与囊性纤维化JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02686 -2020欧元SP - 2002686 AU Frauchiger贝蒂娜s . AU - Binggeli塞维林盟——Yammine苏菲AU - Spycher,本盟-克鲁格,林恩AU -拉姆齐,凯瑟琳·a . AU - Latzin菲利普Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/12/10/13993003.02686 2020.——抽象N2原理而肺部清除指数(LCI)是一个敏感的标志在囊性纤维化患者小气道疾病(CF),纵向变化所知甚少在LCI常规的临床监测。目的描述CF患儿在常规临床监测中LCI的纵向病程，并评估其影响因素。方法在2011年至2018年期间，3 - 18岁的CF患儿每3个月进行一次LCI测量，作为常规临床护理的一部分。我们记录了每次就诊的临床资料。我们使用多水平混合效应模型来确定LCI随时间的变化，并确定影响LCI进程的临床因素。我们收集了78名参与者的1204次访问(3603个试验)的LCI数据，其中907次访问具有可接受的LCI数据。整个人群的平均未调整LCI增加为0.29 LCI单位·年- 1 (95% CI 0.20-0.38)。LCI的增加在青春期更为明显，为0.41个单位·年- 1 (95% CI 0.27-0.54)。铜绿假单胞菌或烟曲霉定植、肺加重、cf相关性糖尿病和支气管肺曲霉病与LCI随时间升高相关。调整临床危险因素后，LCI随时间的增加减少到0.24 LCI单位·年- 1 (95% CI 0.16-0.33)。结论在常规临床监测中测量的LCI与CF患儿的潜在疾病进展有关。随着时间的推移，LCI变化的增加应促使进一步的诊断干预。脚注本手稿最近已被接受发表在欧洲呼吸杂志。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Frauchiger has nothing to disclose.Conflict of interest: Dr. Binggeli has nothing to disclose.Conflict of interest: Dr. Yammine reports grants from Swiss National Science Foundation, outside the submitted work.Conflict of interest: Dr. Spycher reports grants from Swiss National Science Foundation, grants from Swiss Cancer League, outside the submitted work.Conflict of interest: Dr. Krüger has nothing to disclose.Conflict of interest: Dr. Ramsey reports grants from Swiss National Science Foundation, outside the submitted work.Conflict of interest: Dr. Latzin reports grants from Vertex, during the conduct of the study; personal fees from Vertex, personal fees from Novartis, personal fees from Roche, personal fees from Polyphor, personal fees from Vifor, personal fees from Gilead, personal fees from Schwabe, personal fees from Zambon, personal fees from Santhera, grants from Vertex, outside the submitted work. ER -