% 0期刊文章% McEvoy,辛迪Shorey-K t . %endrick, Lyndsey E. %A Milner, Kristin %A Schilling, Diane %A Tiller, Christina %A Vuylsteke, Brittany %A Scherman, Ashley %A Jackson, Keith %A Haas, David M. %A Harris, Julia %A Park, Byung S. %A Vu, Annette %A Kraemer, Dale F. %A Gonzales, David %A Bunten, Carol %A Spindel, Eliot R. %A Morris, Cynthia D. %A Tepper, Robert S. %T Vitamin C to pregnant smokers persistently improves infant airway function to 12 months of age: a randomised trial %D 2020 %R 10.1183/13993003.02208-2019 %J European Respiratory Journal %P 1902208 %V 56 %N 6 %X Background Vitamin C (500 mg·day−1) supplementation for pregnant smokers has been reported to increase newborn pulmonary function and infant forced expiratory flows (FEFs) at 3 months of age. Its effect on airway function through 12 months of age has not been reported.Objective To assess whether vitamin C supplementation to pregnant smokers is associated with a sustained increased airway function in their infants through 12 months of age.Methods This is a pre-specified secondary outcome of a randomised, double-blind, placebo-controlled trial that randomised 251 pregnant smokers between 13 and 23 weeks of gestation: 125 to 500 mg·day−1 vitamin C and 126 to placebo. Smoking cessation counselling was provided. FEFs performed at 3 and 12 months of age were analysed by repeated-measures analysis of covariance.Results FEFs were performed in 222 infants at 3 months and 202 infants at 12 months of age. The infants allocated to vitamin C had significantly increased FEFs over the first year of life compared to those allocated to placebo. The overall increased flows were 40.2 mL·s−1 for at FEF75 (75% of forced vital capacity (FVC)) (adjusted 95% CI for difference 6.6–73.8; p=0.025); 58.3 mL·s−1 for FEF50 (10.9–105.8; p=0.0081); and 55.1 mL·s−1 for FEF25–75 (9.7–100.5; p=0.013).Conclusions In offspring of pregnant smokers randomised to vitamin C versus placebo, vitamin C during pregnancy was associated with a small but significantly increased airway function at 3 and 12 months of age, suggesting a potential shift to a higher airway function trajectory curve. Continued follow-up is underway.Vitamin C supplementation coupled with smoking cessation counselling for pregnant smokers may be a safe, inexpensive, and simple intervention to improve the airway function of their offspring through 12 months of age https://bit.ly/3fa8q2X %U //www.qdcxjkg.com/content/erj/56/6/1902208.full.pdf