TY - JOUR T1 -维生素C对怀孕吸烟者持续改善婴儿气道功能至12个月:一个随机试验JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02208 -2019欧元六世- 56 - 6 SP - 1902208 AU McEvoy辛迪·t . AU - Shorey-Kendrick Lyndsey e . AU -米尔纳,克里斯汀AU -先令,黛安娜AU -舵柄,克里斯蒂娜盟——Vuylsteke布列塔尼非盟- Scherman阿什利AU -杰克逊,基思盟-哈斯,David M. AU - Harris, Julia AU - Park, Byung S. AU - Vu, Annette AU - Kraemer, Dale F. AU - Gonzales, David AU - Bunten, Carol AU - Spindel, Eliot R. AU - Morris, Cynthia D. AU - Tepper，据报道，怀孕吸烟者补充维生素C (500 mg·day−1)可增加新生儿肺功能和婴儿3个月大时的用力呼气流量(fef)。其对12个月大时气道功能的影响尚未见报道。目的评估孕妇吸烟者补充维生素C是否与婴儿12个月后持续气道功能增加有关。这是一项随机、双盲、安慰剂对照试验的一个预先确定的次要结果，该试验将251名怀孕13 - 23周的吸烟孕妇随机分组:维生素C 125 - 500mg·天−1，安慰剂组126名。提供了戒烟咨询。对3个月和12个月时进行的fef进行重复测量协方差分析。结果3月龄婴儿222例，12月龄婴儿202例。与服用安慰剂的婴儿相比，服用维生素C的婴儿在出生第一年的fef显著增加。 The overall increased flows were 40.2 mL·s−1 for at FEF75 (75% of forced vital capacity (FVC)) (adjusted 95% CI for difference 6.6–73.8; p=0.025); 58.3 mL·s−1 for FEF50 (10.9–105.8; p=0.0081); and 55.1 mL·s−1 for FEF25–75 (9.7–100.5; p=0.013).Conclusions In offspring of pregnant smokers randomised to vitamin C versus placebo, vitamin C during pregnancy was associated with a small but significantly increased airway function at 3 and 12 months of age, suggesting a potential shift to a higher airway function trajectory curve. Continued follow-up is underway.Vitamin C supplementation coupled with smoking cessation counselling for pregnant smokers may be a safe, inexpensive, and simple intervention to improve the airway function of their offspring through 12 months of age https://bit.ly/3fa8q2X ER -