@article {McEvoy1902208作者= {McEvoy辛迪t和Shorey-Kendrick Lyndsey大肠和米尔纳,克里斯汀和先令,黛安娜和舵柄,克里斯蒂娜和Vuylsteke,布列塔尼和Scherman,阿什利和杰克逊,基斯和哈斯,大卫·m·哈里斯和茱莉亚和公园,Byung S Vu,安妮特Kraemer,戴尔·f·冈萨雷斯,大卫和Bunten,卡罗和斯宾德尔,艾略特·r·莫里斯,辛西娅·d·珀,罗伯特·S。},标题={维生素C对怀孕吸烟者持续改善婴儿呼吸道功能到12个月的年龄:一个随机试验},体积= {56}= {6},elocation-id = {1902208} = {2020}, doi ={10.1183/13993003.02208 -2019},出版商={欧洲呼吸学会},文摘={背景维生素C(500毫克{\ textperiodcentered}普通人)补充怀孕吸烟者报道增加新生儿肺功能和婴儿用力呼气流量(fef)在3个月的年龄。188bet官网地址通过12个月的年龄影响气道功能还没有被报道。目的评估补充维生素C是否怀孕的吸烟者与持续增加气道功能通过12个月大的婴儿。方法这是一个预先确定的二级结果的随机,双盲,安慰剂对照试验,随机251怀孕吸烟者13至23周的妊娠:{\ textperiodcentered}普通人每天125到500毫克的维生素C和126安慰剂。戒烟咨询。fef执行3和12个月的年龄被重复测量分析了协方差分析。fef结果表现在222名婴儿在3个月,202名婴儿在12个月的年龄。分配给维生素C的婴儿在生命的第一年显著增加fef相比安慰剂分配。整体流动增加40.2毫升{\ textperiodcentered} s - 1在FEF75(75 \ %的用力肺活量(FVC))(调整95 \ % CI差异6.6 {\ textendash} 73.8;p = 0.025); 58.3 mL{\textperiodcentered}s-1 for FEF50 (10.9{\textendash}105.8; p=0.0081); and 55.1 mL{\textperiodcentered}s-1 for FEF25{\textendash}75 (9.7{\textendash}100.5; p=0.013).Conclusions In offspring of pregnant smokers randomised to vitamin C versus placebo, vitamin C during pregnancy was associated with a small but significantly increased airway function at 3 and 12 months of age, suggesting a potential shift to a higher airway function trajectory curve. Continued follow-up is underway.Vitamin C supplementation coupled with smoking cessation counselling for pregnant smokers may be a safe, inexpensive, and simple intervention to improve the airway function of their offspring through 12 months of age https://bit.ly/3fa8q2X}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/56/6/1902208}, eprint = {//www.qdcxjkg.com/content/56/6/1902208.full.pdf}, journal = {European Respiratory Journal} }