TY-JUR T1 - 精密医学地平线的表观生物学和肺病：评论JF - 欧洲呼吸期刊Jo - EUR RESPIR J DO - 10.1183/13993003.03406-2020 SP - 2003406 Au - Benincasa，Giuditta Au - Demeo，Dawn L.Au - Glass，Kimberly Au - Silverman，Edwin K. Au - Napoli，Claudio Y1 - 2020 / 01/01 UR - //www.qdcxjkg.com/content/early/2020/11/11/13993003/11/13993003/11/13993003.03406-2020摘要N2 - 表观遗传机制代表潜在的分子途径，可以弥合遗传背景与导致肺病发病机制的遗传背景和环境风险因素之间的差距。在慢性阻塞性肺病（COPD），哮喘和肺动脉高压（PAH）的患者中，出现异常表观遗传标记的新发现，主要包括DNA甲基化和组蛋白修饰，其直接向DNA介导不影响基因组序列的可逆修饰。翻译后事件和MicroRNA也可以表现出外观调节并可能参与疾病发病机制。因此，可以在外周血，痰，鼻和颊拭子或肺组织中检测到新的致病机制和推定的生物标志物。此外，DNA甲基化在胎儿发育的早期阶段发挥着重要作用，可能受到环境暴露的影响，最终影响个人对生活中的易感性，哮喘和PAH的易感性。随着OMICS平台的进步和计算生物学工具的应用，在网络框架中建模表观遗传可变性，而不是单一的分子缺陷，正在为COPD，哮喘和PAH发病机制的可能分子途径提供见解。表观遗传修饰可能具有临床应用作为肺疾病的非侵袭性生物标志物。此外，将分子测定与表观组织数据的网络分析相结合，可以有助于澄清从“预疾病”到“疾病”状态的多阶段过渡，其目的是提高肺病的初步预防及其随后的临床管理。我们 describe epigenetic mechanisms known to be associated with pulmonary diseases and discuss how network analysis could improve our understanding of lung diseases.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Matson has nothing to disclose.Conflict of interest: Dr. Benincasa has nothing to disclose.Conflict of interest: Dr. DeMeo has nothing to disclose.Conflict of interest: Dr. Glass has nothing to disclose.Conflict of interest: Dr. Silverman has nothing to disclose.Conflict of interest: Dr. Napoli has nothing to disclose. ER -