TY - T1的稳态和early-recruited CD101 <一口>−< /一口>嗜酸性粒细胞抑制endotoxin-induced急性肺损伤JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02354 -2019欧元六世- 56 - 5 SP - 1902354 AU -陈竺盟胡庆余堂翁AU - Ling-Ren周盟曹曹AU -范李盟Yin-Fang吴盟严萍吴盟苗族李盟-胡越盟Jia-Xin沈盟徐方Xiong AU -沼泽局域网盟Li-Xia夏盟本张盟-郝张盟人黄盟- Song-Min应盟Hua-Hao沈盟- Zhi-Hua陈盟温家宝李Y1 - 2020/11/01 UR - //www.qdcxjkg.com/content/56/5/1902354.abstract N2 -介绍急性肺损伤(ALI)是一种致命的严重中性粒细胞炎症,但如果按照条件虽然对嗜酸性粒细胞的功能在阿里的发病机理。我们的目标是调查在阿里嗜酸性粒细胞的作用和分子机制。肺嗜酸性粒细胞通过流式细胞术方法。老鼠与丰富或缺乏嗜酸性粒细胞。多孔性嗜酸性粒细胞,中性粒细胞在支气管肺泡灌洗液,炎症性评估和存活率测定。人类样本也用于验证实验结果。结果血液嗜酸性粒细胞增加幸存的急性呼吸窘迫综合征(ARDS)患者独立于皮质类固醇的使用。存在稳态嗜酸性粒细胞在老鼠和这些自我平衡的嗜酸性粒细胞肺实质,主要源自骨髓,CD101−。更多CD101−嗜酸性粒细胞可以招募比脂多糖(LPS)发起的中性粒细胞炎症。嗜酸性粒细胞增广LPS-induced肺损伤。稳态CD101−嗜酸性粒细胞,改善过敏CD101 +嗜酸性粒细胞加剧时,中性粒细胞炎症引起的有限合伙人。 Likewise, CD101 expression in eosinophils from ARDS patients did not differ from healthy subjects. Mechanistically, CD101− eosinophils exhibited higher levels of Alox15 and Protectin D1. Administration of Protectin D1 isomer attenuated the neutrophilic inflammation.Conclusions Collectively, our findings identify an uncovered function of native CD101− eosinophils in suppressing neutrophilic lung inflammation and suggest a potential therapeutic target for ALI.Eosinophils, a type of immune cell easily overlooked in nonallergic inflammatory diseases, could reside and be rapidly recruited into lungs to suppress endotoxin-induced acute lung injury https://bit.ly/3dyvCaD ER -