TY - JOUR T1 -在荷兰消除儿童和青少年结核病:流行病学国家监测数据时间序列分析JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01086 -2020欧元六世- 56 - 4 SP - 2001086 AU Gafar Fajri盟——Ochi太极拳非盟- van Boveneind-Vrubleuskaya,娜塔莎盟——Akkerman应该w . AU - Erkens,康妮AU - van den霍夫,苏珊AU -范德·沃夫Tjip s . AU - Alffenaar Jan-Willem c . AU - WilffertBob Y1 - 2020/10/01 UR - //www.qdcxjkg.com/content/56/4/2001086.abstract N2 -背景结核病(TB)在儿童和青少年中是持续传播的前哨事件。在荷兰，儿童和青少年结核病的流行病学特征尚未得到充分评估。因此，我们的目标是评估这一人群中的结核病流行病学，为消除结核病提供指导。方法采用1993-2018年国家监测数据，对患有结核病的儿童(15岁以下)和青少年(15 - 19岁)进行回顾性时间序列分析。泊松回归模型与对数种群大小被用来估计通知率和比率。采用分段线性回归分析的平均年度百分比变化(AAPC)估计通知率的趋势。在1993-2018年期间通报的3899名结核病儿童和青少年中，2418人(62%)是在国外出生的(1755名儿童中725人(41.3%)，2144名青少年中1693人(78.9%))。儿童的总体通报率为2.3 / 10万人年，在研究期间稳步下降(AAPC - 10.9%， 95% CI - 12.6 - 9.1)。 In adolescents, the overall notification rate was 8.4 per 100 000 person-years, strongly increasing during 1993–2001 and 2012–2018. Compared to Dutch-born children and adolescents, substantially higher notification rates were observed among African-born children and adolescents (116.8 and 316.6 per 100 000 person-years, respectively). Additionally, an increasing trend was observed in African-born adolescents (AAPC 18.5%, 95% CI 11.9–25.5). Among the foreign-born population, those from countries in the horn of Africa contributed most to the TB caseload.Conclusion TB notification rate among children was low and constantly declining across different demographic groups. However, heterogeneities were shown in adolescents, with an increasing trend in the foreign-born, particularly those from Africa.During 1993–2018, TB notification in children in the Netherlands declined steadily, but there was an increase of TB in foreign-born adolescents. Enhancing active case-finding through contact investigation and entry screening is needed to optimise TB control. https://bit.ly/36AjNhm ER -