% 0期刊文章% Gafar, Fajri % Ochi,太极%一辆货车Boveneind-Vrubleuskaya,娜塔莎% Akkerman,应该Erkens w . %,康妮% van den霍夫,苏珊%范德·沃夫Tjip s % Alffenaar, Jan-Willem c % Wilffert,鲍勃% T对消除儿童和青少年肺结核在荷兰:a流行病学时间序列分析国家监测数据%D 2020 %R 10.1183/13993003.01086-2020 %J欧洲呼吸杂志%P 2001086 %V 56 %N 4 %X儿童和青少年背景结核病(TB)是持续传播的前哨事件。在荷兰，儿童和青少年结核病的流行病学特征尚未得到充分评价。因此，我们的目的是评估这一人群中的结核病流行病学，为消除结核病提供指导。方法利用1993-2018年国家结核病监测数据，对儿童(<15岁)和青少年(15 - 19岁)结核病患者进行回顾性时间序列分析。泊松回归模型用对数种群大小偏移来估计通知率和率比。根据分段线性回归分析，使用平均年百分比变化(AAPC)估计通报率的趋势。结果在1993-2018年报告的3899名儿童和青少年中，2418名(62%)是外国出生的(1755名儿童中725名(41.3%)，2144名青少年中1693名(78.9%))。儿童的总体通知率为2.3 / 10万人年，在研究期间稳步下降(AAPC−10.9%，95% CI−12.6 - 9.1)。在青少年中，总体通报率为每10万人年8.4人，在1993-2001年和2012-2018年期间大幅增加。 Compared to Dutch-born children and adolescents, substantially higher notification rates were observed among African-born children and adolescents (116.8 and 316.6 per 100 000 person-years, respectively). Additionally, an increasing trend was observed in African-born adolescents (AAPC 18.5%, 95% CI 11.9–25.5). Among the foreign-born population, those from countries in the horn of Africa contributed most to the TB caseload.Conclusion TB notification rate among children was low and constantly declining across different demographic groups. However, heterogeneities were shown in adolescents, with an increasing trend in the foreign-born, particularly those from Africa.During 1993–2018, TB notification in children in the Netherlands declined steadily, but there was an increase of TB in foreign-born adolescents. Enhancing active case-finding through contact investigation and entry screening is needed to optimise TB control. https://bit.ly/36AjNhm %U //www.qdcxjkg.com/content/erj/56/4/2001086.full.pdf