泰——的T1肺部清除指数检测不完整的肺功能恢复与学龄儿童急性呼吸道事件与囊性纤维化JF -欧洲呼吸杂志》乔和J做欧元- 10.1183/13993003.国会- 2020.4314六世- 56 - 64 SP - 4314 AU - Perrem,露西盟——Stanojevic Sanja AU -肖,米歇尔AU -詹森,蕾妮盟——圭多,茱莉亚盟-所罗门,梅林达盟——Grasemann Hartmut Sweezey AU -尼尔AU -戴维斯,斯蒂芬妮AU -桑德斯,D.B盟——麦当劳,南希AU -艾萨克,莎拉AU - hara西尔维娅盟——Clem查尔斯盟——Ratjen Felix Y1 - 2020/09/07 UR - //www.qdcxjkg.com/content/56/suppl_64/4314.abstract N2 -背景:我们之前证实，在患有囊性纤维化(CF)的学龄前儿童中，肺清除指数(LCI)随着急性呼吸事件(ARE)而恶化(Rayment, Thorax 2018)。我们现在正在描述are在学龄儿童中的功能后果。方法:我们将这项多位点前瞻性观察研究扩展到学龄儿童。LCI和FEV1每季度测量一次，并在两年的ARE期间进行测量。我们纳入了肺加重(PEx)，定义为使用抗生素治疗，以及未经治疗的咳嗽事件增加(UIC)。在一个广义估计方程模型内的线性回归，考虑重复事件，被用来比较最近稳定访问的变化。结果:我们纳入103名受试者，平均年龄9.8岁(5-16.8岁)。对360例稳定来访、83例PEx和50例UIC进行分析。平均(范围)入学时LCI和FEV1分别为9.5个单位(5.9-17.2)和93%的预测(39-125)。 LCI and FEV1 worsened with both PEx and UIC and did not recover at the next consecutive follow-up visit. At the first stable visit after follow-up, neither LCI or FEV1 recovered to baseline for the PEx group, and, for the UIC group, only FEV1 recovered.Conclusion: In school-age children with CF, lung function does not recover to baseline after PEx and, as detected by LCI, recovery is also incomplete after UIC.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4314.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -