TY -的T1 -一个高风险气道mycobiome正是频繁COPD exacerbators JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.国会做欧元2020.4933六世- 56 - 64 SP - 4933 AU Tiew裴绮AU -讨价还价,艾莉森AU -基尔,冬青R盟——Poh茂白尾海雕盟,彭日成Sze Lei盟——马塔,斯里兰卡Anusha AU -蔡Branden齐豫盟——徐Huiying AU - Koh,圆子Siyue盟——三通,奥古斯汀盟——Abisheganaden约翰Arputhan盟——咀嚼,蒂姆福盟-米勒,布鲁斯·E AU - Tal-Singer露丝非盟-查尔默斯,詹姆斯·d . AU - Chotirmall桑杰H Y1 - 2020/09/07 UR - //www.qdcxjkg.com/content/56/suppl_64/4933.abstract N2 -背景:关于慢性阻塞性肺病菌群的研究还很缺乏。方法:我们对来自亚洲(新加坡和马来西亚)和英国(苏格兰)的患者(n=380)进行了最大的多中心COPD真菌群落评估。非疾病对照组(n=47)在病情恶化期间和之后(n=34)进行了评估和纵向分析。根据死亡率和血清特异性ige对选定真菌的发生情况检测COPD菌群。结果:COPD中存在明显的真菌菌群分布，α-多样性增加(p<0.001)证明了这一点。显著差异(包括更大的真菌间相互作用(共现))表现为非常频繁的病情加重(PERMANOVA，校正p<0.001)。在病情恶化期间和之后的纵向分析显示，抗生素和糖皮质激素不会影响菌群谱。无监督的聚类结果在2个患者组:一个症状增加(CAT评分)和酵母菌优势，第二个经常加重&以曲霉、青霉菌和弯孢菌为特征的高死亡率。 Serum specific IgE levels were elevated against fungi characterizing the ‘high-risk’ group.Conclusion: Frequent COPD exacerbators are characterized by Aspergillus, Penicillium and Curvularia and illustrate poorer survival and systemic specific-IgE responses against these fungi allowing COPD risk stratification based on airway mycobiomes.Funding: Singapore Ministry of Health’s National Medical Research Council under its Research Training Fellowship (NMRC/Fellowship/0049/2017) (P.Y.T) and Clinician-Scientist Individual Research Grant (MOH-000141) (S.H.C). The TARDIS study is funded by Glaxosmithkline & British Lung Foundation (Fellowship to JDC).FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4933.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -