188bet官网地址RT Journal Article SR Electronic T1 Azithromycin prevents airway epithelial barrier dysfunction induced by sulphur dioxide inhalation JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 4782 DO 10.1183/13993003.congress-2020.4782 VO 56 IS suppl 64 A1 Kricker, Jennifer A1 Gudjonsson, Thorarinn A1 Arason, Ari Jon A1 Joelsson, Jon Pétur A1 Valdimarsdottir, Bryndis A1 Gardarsson, Fridrik Runar A1 Page, Clive A1 Lehmann, Fredrik A1 Ingthorsson, Saevar YR 2020 UL //www.qdcxjkg.com/content/56/suppl_64/4782.abstract AB Azithromycin (AZM) is a macrolide which is effective in the treatment of several airway diseases induced by bacterial or environmental insults.前文显示AZM对空气道上膜(AE)增强屏障效果为了分析AZM维沃增强屏障效果,我们用二氧化硫向小鼠挑战以诱导AE屏障失效老鼠接触50-400ppmSO2气体0.5-4小时并监控7天后收集分析AE屏障函数通过测量人体血清相册渗入ABLFHSA注入小鼠尾静脉前一小时牺牲,BALF采伐,HSA浓度由ELISA测量接触SO2前AZM操作导致HSA下降,表示AZM对AE的保护效果AZM处理动物中发现细胞内蒸发和滑动体编队Glututione-S-transferases(GSTs)类酶帮助维护细胞完整性,在SO2处理小鼠中减少s2接触鼠对BALF质谱分析显示,用AZM处理小鼠可提高BALFGST浓度,表示AZM处理与GST浓度下降相关联最后,我们展示AZM对AE屏障完整性的保护效果,可能通过稳定细胞内微环境并便利LBs编组,进一步深入了解LBs在治疗空气道疾病方面的有效性.FoototesCe56:Supplation64,4782.该文摘提交2020ERS国际大会会议“COVID-19前代恢复病毒”。无全文版可用随附该文集的更多资料可在网站www.ers-education.org上查取(ERS成员仅存取)。