PT -期刊文章盟Singhal Pratibha盟——Lunia Prajay盟——Salgia Kapil AU -赛义德,族长TI -环丝氨酸诱导神经毒性的发生率在耐药结核病患者参加三级保健医院援助2020.1593 - 10.1183/13993003.国会DP - 2020 9月07 TA -欧洲呼吸杂志》第六PG - 1593 - 56 IP - 5 64 4099 //www.qdcxjkg.com/content/56/suppl_64/1593.short 4100——//www.qdcxjkg.com/content/56/suppl_64/1593.full——欧元和J2020 9月07;56 AB -介绍:环丝氨酸ATT B组第二线药物(世卫组织)中使用剂量的10 - 15毫克/公斤。而环丝氨酸诱发精神影响是众所周知的,但神经毒性不是通常与一些报告病例确诊。的目标,目的:研究环丝氨酸诱导神经毒性的发生率,神经影像学发现耐药结核病的患者。方法:回顾性研究病人的耐药结核病(MDR, Pre XDR,XDR TB)参加三级保健医院在过去的5年。93例,89人入学资格收到环丝氨酸作为方案的一部分,按照标准的建议。结果:3/89(3.37%)的患者(2男1女)between15-35年发达的神经毒性和神经影像学的变化形式的提单对称限制扩散在齿状核。2患者中枢神经系统耐多药结核病诊断脑脊液焦磷酸测序。 Both developed worsening headache after Rx, I at 1 & other 11 month of Rx. 3rd patient was diagnosed as MDR PTB on BAL TB culture & DST. He developed seizure after 3 months of Rx. After cessation of cycloserine all patients has resolutions of symptoms early & neuroimaging changes reversed on MRI (done 1 yr later) of stopping cycloserine.Conclusion: Our study suggests cycloserine induced neurotoxicity with neuroimaging changes is 3.37 %. No correlation with duration of Rx noted. Identifying cycloserine as cause of neurotoxicity can be challenging due to concurrent administration of other drugs. Neuroimaging in such cases can help in confirming diagnosis of cycloserine neurotoxicity & guide necessary changes to treatment to prevent morbidity & mortality.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1593.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).