% 0期刊文章% Arinze, Johnmary T % Verhamme,凯蒂·m·c·卢伊克%,安玛丽i %一个前锋,布鲁诺%范·穆尔,乔伊斯·b·J . % Brusselle,家伙g . % T慢性咳嗽、慢性疼痛的相关性的2020% % D J R 10.1183/13993003.02651 -2020%欧洲呼吸杂志% P 2002651 % X背景因为慢性咳嗽常见的神经生物学机制和病理生理学与慢性疼痛、临床疾病可能是相互关联的。因此,我们研究了慢性咳嗽、慢性疼痛之间的关系在成人受试者在鹿特丹的研究中,大量潜在人群为基础的队列研究。方法使用一个标准化的问卷,慢性疼痛是疼痛定义为持续6个月,分为每周/每月或每日疼痛的频率。慢性咳嗽被形容为日常咳嗽至少3个月时间。纵向和横向联系是双向调查。结果7141名受试者的研究中,54% (n = 3888)报道慢性疼痛在基线。每日的co-prevalence慢性疼痛和慢性咳嗽是4.4%。慢性咳嗽是更普遍的主题与每日和每周/每月慢性疼痛与那些没有慢性疼痛(13.8%,10.3%,8.2%,p < 0.001)。潜在的混杂因素调整之后,普遍的慢性疼痛明显与事件相关的慢性咳嗽(或1.47,95%可信区间1.08 - -1.99)。协会仍显著对象日常慢性疼痛(或1.49,95%可信区间1.06 - -2.11)和类似的效应估计,虽然与那些每周/每月慢性疼痛(或1.43,95%可信区间0.98 - -2.10)。covariables调整之后,慢性咳嗽患者患慢性疼痛的重大风险(或1.63,95%可信区间1.02 - -2.62)而无慢性咳嗽。Conclusion Chronic cough and chronic pain confer risk on each other among adult subjects, indicating that both conditions might share common risk factors and/or pathophysiologic mechanisms.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Arinze reports grants from MSD, outside the submitted work;.Conflict of interest: KV works for a research group who in the past received unconditional grants from Yamanouchi, Pfizer/Boehringer Ingelheim, Novartis, GSK none of which relate to the content of this work.Conflict of interest: Dr. Luik has nothing to disclose.Conflict of interest: Dr. Stricker has nothing to disclose.Conflict of interest: Dr. van Meurs has nothing to disclose.Conflict of interest: Dr. Brusselle reports personal fees from Astra Zeneca, personal fees from Boehringer-Ingelheim, personal fees from Chiesi, personal fees from Glaxo Smith Kline, personal fees from Novartis, personal fees from Sanofi, personal fees from Teva, grants from MSD, outside the submitted work;. %U //www.qdcxjkg.com/content/erj/early/2020/10/22/13993003.02651-2020.full.pdf