@Article {Arinze2002651，作者= {Arinze，Johnmary T.和Verhamme，Katia M. C.和Luik和Luik，Annemarie I.和Stricker，Bruno和Van Meurs，Joyce B. J.和Brusselle，Guy G.}和慢性疼痛}，Elocation-id = {2002651}，Year = {2020}，doi = {10.1183/13993003.02651-2020}，Publisher = {欧洲呼吸社会}，摘要= {背景188bet官网地址= {背景，因为慢性咳嗽具有常见的神经生物学机械学和Pathopathyphysiologysismss和Pathopathyphysiologysismss和Pathopathyphysiologysismss和Pathopathyphysiology ankylysiology andopathysiologysismss。由于慢性疼痛，两种临床疾病可能会相互关联。因此，我们在鹿特丹研究中检查了成人受试者的慢性咳嗽和慢性疼痛之间的关联每周/每月或每日疼痛的频率。慢性咳嗽被描述为每天咳嗽至少持续3个月。对纵向和横截面关联进行了双向研究。该研究中的7141名受试者的分辨率为54 \％（n = 3888），报道了基线时慢性疼痛。每日慢性疼痛和慢性咳嗽的共同价值为4.4 \％。与没有慢性疼痛的受试者相比，每天和每周/每月慢性疼痛的受试者（13.8 \％\％和10.3 \％对8.2 \％，p \ <0.001）的慢性咳嗽更为普遍。调整了潜在混杂因素后，普遍的慢性疼痛与入射慢性咳嗽显着相关（OR 1.47，95 \％CI 1.08 {\ Textendash} 1.99）。 The association remained significant in subjects with daily chronic pain (OR 1.49, 95\% CI 1.06{\textendash}2.11) with a similar effect estimate, albeit non-significant, in those with weekly/monthly chronic pain (OR 1.43, 95\% CI 0.98{\textendash}2.10). After adjustment for covariables, subjects with chronic cough had a significant risk of developing chronic pain (OR 1.63, 95\% CI 1.02{\textendash}2.62) compared with those without chronic cough.Conclusion Chronic cough and chronic pain confer risk on each other among adult subjects, indicating that both conditions might share common risk factors and/or pathophysiologic mechanisms.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Arinze reports grants from MSD, outside the submitted work;.Conflict of interest: KV works for a research group who in the past received unconditional grants from Yamanouchi, Pfizer/Boehringer Ingelheim, Novartis, GSK none of which relate to the content of this work.Conflict of interest: Dr. Luik has nothing to disclose.Conflict of interest: Dr. Stricker has nothing to disclose.Conflict of interest: Dr. van Meurs has nothing to disclose.Conflict of interest: Dr. Brusselle reports personal fees from Astra Zeneca, personal fees from Boehringer-Ingelheim, personal fees from Chiesi, personal fees from Glaxo Smith Kline, personal fees from Novartis, personal fees from Sanofi, personal fees from Teva, grants from MSD, outside the submitted work;.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2020/10/22/13993003.02651-2020}, eprint = {//www.qdcxjkg.com/content/early/2020/10/22/13993003.02651-2020.full.pdf}, journal = {European Respiratory Journal} }