TY - T1的高架肺动脉栓塞和严重缺乏抗凝预测PE COVID-19病人JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01811 -2020欧元六世- 56 - 4 SP - 2001811 AU - Basile Mouhat AU -马修Besutti AU -凯文Bouiller盟弗兰克Grillet AU -查尔斯Monnin盟菲奥娜Ecarnot AU -朱利安贝洱盟Gilles Capellier盟Thibaud Soumagne AU - Sebastien Pili-Floury盟Guillaume Besch AU - Guillaume Mourey盟昆汀Lepiller AU -凯瑟琳Chirouze AU -弗朗索瓦•席勒的影子盟Romain萧邦AU -尼古拉斯Meneveau Y1 - 2020/10/01 UR - //www.qdcxjkg.com/content/56/4/2001811.abstract N2 -背景冠状病毒疾病2019 (COVID-19)可能引起静脉血栓栓塞。我们决定因素独立与ct肺动脉造影(CTPA)确诊肺栓塞(PE)在住院严重COVID-19病人。方法在所有(n = 349)患者住院COVID-19在法国大学医院COVID-19率高的地区,我们分析病人CTPA对严重疾病的临床症状(血氧饱和度测量脉搏血氧仪≤93%或呼吸率≥30次·敏−1)或快速临床恶化。多变量分析使用弗斯执行惩罚最大似然估计。结果162例(46.4%)患者接受了CTPA(平均数±标准差为65.6±13.0岁;67.3%男性(95% CI 59.5 - -75.5%)。体育是44例(27.2%)患者的诊断。大多数PEs节段,PE-related右心室功能障碍为15.9%。通过多变量分析,只有两个CTPA-confirmed PE是肺动脉栓塞的重要预测因子水平和缺乏任何抗凝治疗(或4.0 (95% CI 2.4 - -6.7) /额外的四分位数,或4.5 (95% CI 1.1 - -7.4),分别)。接受者操作特征曲线分析了肺动脉栓塞的截止值2590 ng·毫升−1最佳预测发生PE(曲线下的面积0.88,术中;0.001,敏感性83.3%,特异性83.8%)。肺动脉栓塞水平在2590 ng·毫升−1与统计相关的调整风险增加体育。Conclusion Elevated D-dimers (>2590 ng·mL−1) and absence of anticoagulant therapy predict PE in hospitalised COVID-19 patients with clinical signs of severity. These data strengthen the evidence base in favour of systematic anticoagulation, and suggest wider use of D-dimer guided CTPA to screen for PE in acutely ill hospitalised patients with COVID-19.We studied predictors of pulmonary embolism in severe COVID-19 and found that D-dimer level and lack of any anticoagulant therapy were associated with a 17-fold and four-fold increase in PE, respectively, in COVID-19 patients with clinical signs of severity https://bit.ly/2ETfAfo ER -