TY - T1的目标蛋白质组学对心脏适应肺动脉高血压JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02428 -2020欧元SP - 2002428 AU Amsallem Myriam AU -斯韦特,安德鲁J . AU -亚瑟Ataam詹妮弗盟——Guihaire朱利安盟——Lecerf佛罗伦萨AU -兰伯特,梅勒妮盟——Ghigna Maria Rosa AU -阿里,Md Khadem盟——毛Yuqiang Fadel,非盟-埃利盟发布,马琳AU - de Jesus Perez,维尼乔盟——SpiekerkoetterEdda AU - Mercier, Olaf AU - Haddad, Francois AU - Zamanian, Roham T. Y1 - 20/01/01 UR - //www.qdcxjkg.com/content/early/2020/10/08/13993003.02428-2020.abstract N2 -此前没有针对肺动脉高压(PAH)右心室(RV)的蛋白质组学筛选研究。这项研究调查了与PAH右心适应不良表型(RHMP)相关的循环蛋白质组学特征。121例PAH患者(发现队列)和76例患者(验证队列)使用多重免疫分析进行血浆蛋白质组学分析。用偏最小二乘回归评估蛋白质组学标记物与RHMP(由Mayo右心评分[结合RV strain，纽约心脏协会NYHA分级和NT-proBNP]和斯坦福评分[RV收缩期末期重塑指数，NYHA和NT-proBNP]定义)之间的相关性。在PAH患者、对照组和肺动脉带(PAB)小鼠的RV样本中测量生物标志物的表达。在两个队列中，高水平的肝脏生长因子(HGF)、干细胞生长因子β、神经生长因子和基质衍生因子-1与Mayo和Stanford评分较差相关，独立于肺阻力或压力(验证队列具有更严重的疾病特征:较低的心脏指数和较高的NT-proBNP)。在两个队列中，HGF增加了REVEAL评分在预测3年死亡、移植或住院方面的价值。HGF及其受体c-Met的RV表达水平在终末期PAH患者中高于对照组，在PAB小鼠中高于假组。高血浆HGF水平与RHMP相关，可预测3年临床恶化。PAH中HGF和c-Met RV表达水平均升高。 Assessing plasma HGF levels might identify patients at risk for heart failure who warrant closer follow-up and intensified therapy.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Yan reports grants from National Institutes of Health, during the conduct of the study;.Conflict of interest: Dr. Amsallem has nothing to disclose.Conflict of interest: Dr. Sweatt has nothing to disclose.Conflict of interest: Dr. ARTHUR ATAAM has nothing to disclose.Conflict of interest: Dr. Guihaire MD PhD has nothing to disclose.Conflict of interest: Dr. LECERF has nothing to disclose.Conflict of interest: Dr. LAMBERT PHD has nothing to disclose.Conflict of interest: Dr. Ghigna has nothing to disclose.Conflict of interest: Dr. Ali has nothing to disclose.Conflict of interest: Dr. Mao has nothing to disclose.Conflict of interest: Dr. FADEL has nothing to disclose.Conflict of interest: Dr. RABINOVITCH has nothing to disclose.Conflict of interest: Dr. de Jesus Perez has nothing to disclose.Conflict of interest: Dr. Spiekerkoetter has nothing to disclose.Conflict of interest: Dr. MERCIER has nothing to disclose.Conflict of interest: Dr. HADDAD has nothing to disclose.Conflict of interest: Dr. Zamanian has nothing to disclose. ER -