TY - JOUR T1 -冷频率的风险因性别而异:哮喘的作用、年龄、TLR7和白细胞子集JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02453 -2019欧元六世- 56 - 4 SP - 1902453 AU -穆雷,Liisa m . AU - Yerkovich斯蒂芬妮·t . AU -费雷拉,曼努埃尔·a . AU -阿帕姆,N2 -病毒性呼吸道感染通常是良性的，但可引发哮喘加重。与上呼吸道感染(感冒)频率相关的因素尚不完全清楚，也不清楚这些因素在女性和男性之间是否存在差异。为了确定哪些免疫学和临床变量与自我报告的呼吸道感染(感冒)频率相关，招募了150例哮喘病例和151例对照组。抗病毒免疫反应变量:toll样受体(TLR)7/8基因表达、浆细胞样树突状细胞(pDC)数量和干扰素-α、肿瘤坏死因子和白细胞介素-12的产生以及哮喘之间的联系随后被检测，可能解释冷频率。哮喘患者报告称，他们每年更容易感冒(中位数为3比2;p < 0.001)，基线TLR7基因表达较低(优势比0.12;比控制p = 0.02)。许多变量和冷频率之间的关联在女性和男性之间是不同的。在女性中，高血中性粒细胞计数(β=0.096, p=0.002)和年轻(β=−0.017,p<0.001)与更频繁的感冒独立相关，但不与儿童接触。 In men, low TLR7 expression (β=−0.96, p=0.041) and high CLEC4C gene expression (a marker of pDC; β=0.88, p=0.008) were independently associated with more frequent colds. Poor asthma symptom control was independently associated with reduced TLR8 gene expression (β=−1.4, p=0.036) and high body mass index (β=0.041, p=0.004).Asthma, age and markers of inflammation and antiviral immunity in peripheral blood are associated with frequent colds. Interestingly, the variables associated with cold frequency differed between women and men.Asthma, age and blood markers of antiviral immunity associate with cold frequency in a sex-dependent manner. People with asthma have lower TLR7 gene expression than healthy people; only in men does this associate with cold frequency. https://bit.ly/3e3yWKy ER -