TY - JOUR T1 -冷频率的风险因性别而异:哮喘的作用、年龄、TLR7和白细胞子集JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02453 -2019欧元六世- 56 - 4 SP - 1902453 AU -穆雷,Liisa m . AU - Yerkovich斯蒂芬妮·t . AU -费雷拉,曼努埃尔·a . AU -阿帕姆,John W. Y1 - 2020/10/01 UR - //www.qdcxjkg.com/content/56/4/1902453.abstract N2 -病毒性呼吸道感染通常是良性的，但可引发哮喘加重。与上呼吸道感染(感冒)频率相关的因素尚未完全了解，也不清楚这些因素在男女之间是否存在差异。为了确定哪些免疫学和临床变量与自我报告的呼吸道感染(感冒)频率相关，招募了150例哮喘病例和151例对照。抗病毒免疫反应变量之间的关系:toll样受体(TLR)7/8基因表达，浆细胞样树突状细胞(pDC)数量和干扰素-α，肿瘤坏死因子和白细胞介素-12的产生，然后检查哮喘可能解释冷频率。有哮喘病例的人每年报告的感冒次数更多(中位数为3对2;0.001)和较低的基线TLR7基因表达(优势比0.12;比控制p = 0.02)。许多变量与冷频率之间的联系在女性和男性之间存在差异。在女性中，高血中性粒细胞计数(β=0.096, p=0.002)和较年轻的年龄(β=−0.017,p<0.001)，但未接触儿童，与更频繁的感冒是独立相关的。 In men, low TLR7 expression (β=−0.96, p=0.041) and high CLEC4C gene expression (a marker of pDC; β=0.88, p=0.008) were independently associated with more frequent colds. Poor asthma symptom control was independently associated with reduced TLR8 gene expression (β=−1.4, p=0.036) and high body mass index (β=0.041, p=0.004).Asthma, age and markers of inflammation and antiviral immunity in peripheral blood are associated with frequent colds. Interestingly, the variables associated with cold frequency differed between women and men.Asthma, age and blood markers of antiviral immunity associate with cold frequency in a sex-dependent manner. People with asthma have lower TLR7 gene expression than healthy people; only in men does this associate with cold frequency. https://bit.ly/3e3yWKy ER -