TY - Jour T1 - 面对争议：白细胞介素-6和Covid-19细胞因子风暴综合征JF - 欧洲呼吸杂志Jo - Eur Respir J Do - 10.1183 / 13993003.03006-2020 VL - 56是 - 4 SP - 2003006 Au - Chen，Luke Y.C. AU - Hoiland, Ryan L. AU - Stukas, Sophie AU - Wellington, Cheryl L. AU - Sekhon, Mypinder S. Y1 - 2020/10/01 UR - //www.qdcxjkg.com/content/56/4/2003006.abstract N2 - The concept of coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome (COVID-CSS) emerged early in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic to explain why some patients exposed to this virus become critically ill with acute respiratory distress syndrome, multi-organ failure, and death. A seminal study from Wuhan, China reported higher serum concentrations of inflammatory cytokines in patients requiring critical care compared to those with milder disease, and the authors postulated that “cytokine storm was associated with disease severity” [1].Hypercytokinaemic immune dysregulation in COVID-19 is known as cytokine storm syndrome. Interleukin-6 levels ≥80 pg·mL−1 predict an increased risk of respiratory failure and death, and immunomodulatory therapy is an area of urgent investigation. https://bit.ly/3jq3uJ4The authors thank Catherine Biggs for her critical review of the manuscript. ER -