PT - JOURNAL ARTICLE AU - Neder, J. Alberto AU - Berton, Danilo C. AU - Nery, Luiz E. AU - Tan, Wan C. AU - Bourbeau, Jean AU - O'Donnell, Denis E. ED -,TI -在增量周期测功术中评估劳动性呼吸困难强度的参考系AID - 10.1183/13993003.00191-2020 DP -2020年10月01 TA -欧洲呼吸杂志PG - 2000191 VI - 56 IP - 4 4099 - //www.qdcxjkg.com/content/56/4/2000191.short 4100 - //www.qdcxjkg.com/content/56/4/2000191.full SO - Eur Respir J2020年10月01;56 AB -由于缺乏作为工作速率(WR)和通气(V e)函数的参考范围,在递增式心肺运动测试(CPET)中评估呼吸困难严重程度一直受到阻碍。这与骑自行车尤其相关,因为骑行是一种测试方式,它会使腿部肌肉过度劳累,导致腿部不适感加剧。275名20-85岁明显健康的受试者(131名男性)在标准化工作速率和V - e下建立了基于呼吸困难百分位数(0-10博格量表)的参考范围。将它们与随机选择的“验证”样本中记录的值进行比较(n=451;224人)。在167名因腿部不适而终止CPET的慢性呼吸困难调查对象(86名男性)中测试了它们在正确揭示劳力性呼吸困难严重程度方面的有用性。在较小程度上,iso-V - e参考范围(第5 - 25,25 - 50,50 - 75和第75 - 95百分位)随着年龄的变化而增加,女性的系统性更高(p<0.01)。“参考”样本和“验证”样本之间的百分位分布无显著差异(p>0.05)。在118名(91.5%)“测试”样本中,有108名(91.5%)受试者表现出已知可引发劳力性呼吸困难的生理异常,即呼吸效率低下和/或严重吸气限制,次极大呼吸困难-工作率评分在75 - 95或95百分位内。 In contrast, dyspnoea scores typically fell in the 5th–50th range in subjects without those abnormalities (p<0.001).This frame of reference might prove useful to uncover the severity of exertional dyspnoea in subjects who otherwise would be labelled as “non-dyspnoeic” while providing mechanistic insights into the genesis of this distressing symptom.Iso-power and iso-ventilation reference ranges for exertional dyspnoea were prospectively established in men and women aged 20 to 85. This is the first set of normative values to objectively assess the burden of dyspnoea during incremental cycle ergometry. https://bit.ly/2yfftY6