TY - JOUR T1 -樟脑评分:patient-reported结果提高了肺部动脉内膜切除术在慢性血栓栓塞肺动脉高压JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02096 -2019欧元六世- 56 - 4 SP - 1902096 AU -纽汉姆,迈克尔•AU - Bunclark凯瑟琳盟——亚伯拉罕,尼莎非盟-阿里,萨曼莎AU - Amaral-Almeida,Liliana AU - Cannon, John E. AU - Doughty, Natalie AU - Ng, Choo AU - Ponnaberanam, Anie AU - Sheares, Karen AU - Speed, Nicola AU - Taboada, Dolores AU - Toshner, Mark AU - Tsui, Steven AU - Jenkins, David P. AU - Pepke-Zaba，肺动脉内膜切除术(PEA)是符合条件的慢性血栓栓塞性肺动脉高压(CTEPH)患者的推荐治疗方法。剑桥肺动脉高压结局评价(CAMPHOR)评分是一种国际认证的患者报告CTEPH结局(PRO)测量方法。它评估三个领域:活动，生活质量(QoL)和症状。我们评估了接受PEA治疗的CTEPH患者的PROs。这项回顾性观察研究对2006年至2017年在英国国家PEA中心连续接受PEA的CTEPH患者进行了评估，评估了从基线(PEA前)到PEA后5年樟脑评分的变化。将樟脑评分与1)有或无临床显著残余肺动脉高压的患者和2)接受PEA和倾向匹配且未手术的CTEPH患者进行比较。微创临床重要差异(MCID)采用基于锚点的方法计算。Results Out of 1324 CTEPH patients who underwent PEA, 1053 (80%) had a CAMPHOR score recorded pre-PEA, 934 (71%) had a score recorded within a year of PEA and 784 (60%) had both. There were significant improvements between pre- and post-PEA in all three CAMPHOR domains (median±interquartile range activity −5±7, QoL −4±8, symptoms −7±8; all p<0.0001). Improvements in CAMPHOR score were greater and more sustained in those without clinically significant residual pulmonary hypertension. CTEPH patients undergoing PEA had better CAMPHOR scores than those not operated on. The MCID in CAMPHOR score was −3±5 for activity, −4±7 for QoL and −6±7 for symptoms.Conclusions PROs are markedly improved by PEA in patients with CTEPH, more so in those without clinically significant residual pulmonary hypertension.Patients with CTEPH report significant improvement in patient-reported CAMPHOR scores after pulmonary endarterectomy compared with patients not operated on, but those with clinically significant residual pulmonary hypertension have less benefit https://bit.ly/2yU8V1v ER -