TY -的T1 - < em > < / em >假单胞菌和风险的r mitigation for chronic lung allograft dysfunction JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01968-2020 VL - 56 IS - 4 SP - 2001968 AU - Glanville, Allan R. Y1 - 2020/10/01 UR - //www.qdcxjkg.com/content/56/4/2001968.abstract N2 - The relationship between bronchopulmonary Pseudomonas aeruginosa and chronic lung allograft dysfunction (CLAD) has often stimulated considerations of primacy. Which came first, the chicken or the egg? Unlike binary logic, natural circumstances are more complex and demand a pluralistic view of causality, notwithstanding the recognition that in systems of coexistence, mitigation of deleterious outcomes can still be achieved by reducing one of the driving factors in the equation. So it is with airway disease, both large and small, after lung transplantation [1, 2]. Mucosal and structural damage promote an unhealthy local milieu with impaired barrier function, compromised local immunity and reduced efficacy of mucociliary transport. Perturbations of the pulmonary microbiome along with chemical damage from often occult gastric aspiration set the foundation for such a scenario. However, unlike fibrotic luminal occlusion of small airways typical of obliterative bronchiolitis, which is permanent, the damage described above may be amenable to change [3].Univariable analysis supports attempts at “eradicating” Pseudomonas from bronchopulmonary secretions after lung transplantation https://bit.ly/2Nw6h5P ER -