TY-JUR T1 - 在COPD中增量运动期间的通风需求 - 能力不平衡：AN 在Silico 透视JF - 欧洲呼吸期刊JO - EUR RESPIR J Do - 10.1183 / 13993003.00495-2020 VL - 56是 - 3SP - 2000495 Au - Neder，J. Alberto Y1 - 2020/09/01 UR - //www.qdcxjkg.com/content/56/3/2000495.Abstract n2 - 运动不宽容构成了一个主要的患者导向结果COPD [1]。有证据表明所谓的“通气效率低下”（由线性微小通风（V'e）建立给二氧化碳输出（V'Co2）关系（CPET）的（CPET））[2]有一个在该疾病中设定运动耐受的限制方面的重要作用[3]。The rationale is straightforward: the faster V′E increases (i.e. the steeper the V′E–V′CO2 slope), and the higher its resting value (∼y-intercept) [2], the sooner V′E is expected to reach a lower compared to a higher maximum breathing capacity (MBC) [4]. Recognising that V′E close to MBC cannot be sustained for a prolonged period of time without intolerable dyspnoea [5], it can be hypothesised that peak work rate (WR) would change inversely with V′E–V′CO2 slope and intercept, but directly with MBC. Since the first two parameters are influenced by the fraction of V′E “wasted” in the physiological dead space and the “set-point” for the arterial partial pressure for carbon dioxide [2], whereas MBC is linked to the resting ventilatory capacity [6], it is not surprising that the exertional ventilatory demand–capacity relationship varies markedly among patients with COPD [7].The V′E–V′CO2 relationship during incremental exercise has a major impact on peak exercise capacity across the range of COPD severity. https://bit.ly/2RU1fCyThis work is dedicated to the memory of Brian J. Whipp (1937–2011), a pioneer and enthusiast of the concept of ventilatory (in)efficiency as applied to cardiopulmonary diseases. ER -