RT期刊文章SR电子T1晚发性“急性纤维性和组织性肺炎”损害长期肺移植功能和生存JF欧洲呼吸学会SP 1902292 DO 10.1183/13993003.02292-2019 VO 56 IS 3 A1 Vanstapel, Arno A1 Verleden, Stijn E. A1 Weynand, Birgit A1 Verbeken, Eric A1 De Sadeleer, L188bet官网地址aurens A1 Vanaudenaerde, Bart M. A1 Verleden, Geert M. A1 Vos, Robin A1，YR 2020 UL //www.qdcxjkg.com/content/56/3/1902292.abstract AB肺移植后急性纤维性和组织性肺炎(AFOP)与肺功能快速下降有关。但与慢性肺异体移植功能障碍(CLAD)的关系尚不清楚。我们调查了同种异体肺移植活检中AFOP检测与临床重要终点之间的关系。我们回顾了2011-2017年在鲁汶大学医院接受肺移植的468例患者的肺异体移植活检。AFOP分为早期新发(移植后≤90天)或晚期新发(移植后90天);并与无clad生存、移植物生存、供体特异性抗体、气道和血液嗜酸性粒细胞增多有关。早期和晚期AFOP分别有24例(5%)和30例(6%)。晚期AFOP患者无clad生存期显著降低(中位生存期2.42年;p<0.0001)，并与限制性异体移植物综合征的发展相关(or 28.57, 95% CI 11.34-67.88;p < 0.0001)。 Similarly, graft survival was significantly lower in patients with late AFOP (median survival 4.39 years; p<0.0001) compared with patients with early AFOP or without AFOP. Late AFOP was furthermore associated with detection of circulating donor-specific antibodies (OR 4.75, 95% CI 2.17–10.60; p=0.0004) compared with patients with early or without AFOP, and elevated airway and blood eosinophilia (p=0.043 and p=0.045, respectively) compared with early AFOP patients.Late new-onset AFOP is associated with a worse prognosis and high risk of CLAD development, specifically restrictive allograft syndrome. Our findings indicate that late new-onset AFOP might play a role in the early pathogenesis of restrictive allograft syndrome.This study links acute fibrinous and organising pneumonia with poor outcome after lung transplantation. These findings indicate that acute fibrinous and organising pneumonia plays a role in the pathogenesis of restrictive allograft syndrome. https://bit.ly/3aof9n9