TY - T1的迟发性的“急性纤维素性肺炎和组织”损害长期移植肺功能和生存JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02292 -2019欧元六世- 56 - 3 SP - 1902292 AU Vanstapel阿诺盟——Verleden Stijn e . AU - Weynand Birgit盟——Verbeken埃里克•AU - De Sadeleer Laurens AU - Vanaudenaerde,巴特·m . AU - Verleden基尔特•m . AU - Vos,罗宾·A2 - Y1 - 2020/09/01 UR - //www.qdcxjkg.com/content/56/3/1902292.abstract N2 -急性纤维蛋白的和组织相关肺炎(AFOP)肺移植后肺功能迅速下降。然而,与慢性肺部同种异体移植物功能障碍(复合)仍不清楚。我们调查之间的关系检测AFOP异体肺活检的临床重要的端点。我们回顾了从468年异体肺活检病人肺移植医院鲁汶大学(2011 - 2017)。AFOP被归类为最近诊断为早期(≤90天移植后)或最近诊断为晚期(在移植后90天);与CLAD-free生存,移植物存活率,供体特异性抗体,气道嗜酸性粒细胞和血液。早期和晚期AFOP中检测出24(5%)和30例(6%)患者,分别。CLAD-free生存显著低于AFOP晚期患者(平均生存2.42年;术;0.0001)相比,患者早期或没有AFOP特别是与发展相关限制性的同种异体移植物综合征(或28.57,95%可信区间11.34 - -67.88;术中,0.0001)。同样,移植物存活率显著低于AFOP晚期患者平均生存4.39年; p<0.0001) compared with patients with early AFOP or without AFOP. Late AFOP was furthermore associated with detection of circulating donor-specific antibodies (OR 4.75, 95% CI 2.17–10.60; p=0.0004) compared with patients with early or without AFOP, and elevated airway and blood eosinophilia (p=0.043 and p=0.045, respectively) compared with early AFOP patients.Late new-onset AFOP is associated with a worse prognosis and high risk of CLAD development, specifically restrictive allograft syndrome. Our findings indicate that late new-onset AFOP might play a role in the early pathogenesis of restrictive allograft syndrome.This study links acute fibrinous and organising pneumonia with poor outcome after lung transplantation. These findings indicate that acute fibrinous and organising pneumonia plays a role in the pathogenesis of restrictive allograft syndrome. https://bit.ly/3aof9n9 ER -