TY - JOUR T1 -全周抗结核方案:概念验证研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.02502 -2019欧元六世- 56 - 3 SP - 1902502 AU Kort Fatma AU -弗尔涅勒雷,Laure AU - Chauffour Aurelie AU - Jarlier文森特AU - Lounis,该非盟-安德利,柯恩盟——奥布里,亚历山德拉盟——Guglielmetti洛伦佐盟——Veziris世界卫生组织建议监督结核病的治疗。间歇疗法有可能简化监督和提高依从性。我们的目标是分析基于半衰期较长的药物，bedaquiline和利福喷丁的每周一次的治疗方案在小鼠肺结核模型中的消毒作用。方法用×10−6 CFU结核分枝杆菌H37Rv静脉感染300只瑞士小鼠。小鼠每周给药1次:1)吡嗪酰胺(BPZ)、利福喷丁、bedquiline;2) BPZ +莫西沙星;3) BPZM +氯法齐明(BPZMC);4)肺结核每日标准养生法。疗程均为4、6个月。 Bactericidal and sterilising activity were assessed.Results After 2 months of treatment, the mean count in lungs was 0.76±0.60 log10 CFU in mice treated with the daily control regimen and negative in all mice treated with once-weekly regimens (p<0.05 compared to the daily control). All mice had negative lung cultures on completion of either 4 or 6 months of treatment, whereas 3 months after 4 and 6 months of treatment, respectively, the relapse rate was 64% and 13% in the standard daily regimen, 5% and 0% in BPZ, 0% and 0% in BPMZ and 0% and 5% in BPMZC (p<0.05 for all once-weekly regimens versus 4-month daily control; p>0.05 for all once-weekly regimens versus 6-month daily control).Conclusions BPZ-based once-weekly regimens have higher sterilising activity than the standard daily regimen and could greatly simplify treatment administration and possibly shorten the duration of tuberculosis treatment.Bedaquiline–rifapentine–pyrazinamide-based once-weekly regimens have higher sterilising activity than the standard daily regimen of tuberculosis and could thus greatly simplify treatment of tuberculosis https://bit.ly/2W8yx2r ER -