TY - T1的完全公开每周的方案:一个概念验证研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.02502 -2019欧元六世- 56 - 3 SP - 1902502 AU Kort Fatma AU -弗尔涅勒雷,Laure AU - Chauffour Aurelie AU - Jarlier文森特AU - Lounis,该非盟-安德利,柯恩盟——奥布里,亚历山德拉盟——Guglielmetti洛伦佐盟——Veziris尼古拉斯Y1 - 2020/09/01 UR - //www.qdcxjkg.com/content/56/3/1902502.abstract N2 -背景世界卫生组织建议监督治疗肺结核。断断续续的方案有可能简化监督提高合规。我们的目标是分析每周的冲销活动方案基于药物半衰期长,bedaquiline rifapentine,在小鼠模型的肺结核。方法300瑞士感染小鼠静脉注射感染×10−6 CFU结核分枝杆菌H37Rv。老鼠一旦每周治疗方案包含:1)bedaquiline, rifapentine和吡嗪酰胺(BPZ);2)BPZ +莫西沙星(BPZM);3)BPZM +氯法齐明(BPZMC);4)标准的日常养生肺结核。所有方案都给出4或6个月。杀菌和冲销活动进行评估。结果2个月的治疗后,意味着在肺为0.76±0.60 log10 CFU计数小鼠每日控制方案和消极的对待所有老鼠每周处理方案(术中;0.05相比,日常控制)。 All mice had negative lung cultures on completion of either 4 or 6 months of treatment, whereas 3 months after 4 and 6 months of treatment, respectively, the relapse rate was 64% and 13% in the standard daily regimen, 5% and 0% in BPZ, 0% and 0% in BPMZ and 0% and 5% in BPMZC (p<0.05 for all once-weekly regimens versus 4-month daily control; p>0.05 for all once-weekly regimens versus 6-month daily control).Conclusions BPZ-based once-weekly regimens have higher sterilising activity than the standard daily regimen and could greatly simplify treatment administration and possibly shorten the duration of tuberculosis treatment.Bedaquiline–rifapentine–pyrazinamide-based once-weekly regimens have higher sterilising activity than the standard daily regimen of tuberculosis and could thus greatly simplify treatment of tuberculosis https://bit.ly/2W8yx2r ER -