TY - JOUR T1 -全周抗结核方案:概念验证研究JF -欧洲呼吸杂志JO - Eur Respir J DO - 10.1183/13993003.02502-2019 VL - 56 IS - 3 SP - 1902502 AU - Kort, Fatma AU - Fournier Le Ray, Laure AU - Chauffour, Aurélie AU - Jarlier, Vincent AU - Lounis, Nacer AU - Andries, Koen AU - Aubry, Alexandra AU - Guglielmetti, Lorenzo AU - Veziris，Nicolas Y1 - 2020/09/01 UR - //www.qdcxjkg.com/content/56/3/1902502.abstract N2 -背景世界卫生组织建议监督结核病的治疗。间歇性方案有可能简化监督和提高依从性。我们的目的是分析以半衰期较长的药物贝达喹啉和利福喷丁为基础的每周一次方案在结核病小鼠模型中的杀菌活性。方法用×10−6 CFU结核分枝杆菌H37Rv静脉感染300只瑞士小鼠。小鼠每周进行一次治疗，方案包含:1)贝达喹啉，利福喷丁和吡嗪酰胺(BPZ);2) BPZ +莫西沙星(BPZM);3) BPZM +氯法齐明(BPZMC);4)结核病的标准日常养生。所有方案均给予4或6个月。 Bactericidal and sterilising activity were assessed.Results After 2 months of treatment, the mean count in lungs was 0.76±0.60 log10 CFU in mice treated with the daily control regimen and negative in all mice treated with once-weekly regimens (p<0.05 compared to the daily control). All mice had negative lung cultures on completion of either 4 or 6 months of treatment, whereas 3 months after 4 and 6 months of treatment, respectively, the relapse rate was 64% and 13% in the standard daily regimen, 5% and 0% in BPZ, 0% and 0% in BPMZ and 0% and 5% in BPMZC (p<0.05 for all once-weekly regimens versus 4-month daily control; p>0.05 for all once-weekly regimens versus 6-month daily control).Conclusions BPZ-based once-weekly regimens have higher sterilising activity than the standard daily regimen and could greatly simplify treatment administration and possibly shorten the duration of tuberculosis treatment.Bedaquiline–rifapentine–pyrazinamide-based once-weekly regimens have higher sterilising activity than the standard daily regimen of tuberculosis and could thus greatly simplify treatment of tuberculosis https://bit.ly/2W8yx2r ER -