TY - T1的血清学特点SARS-CoV-2感染暴露和post-symptom后出现JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00763 -2020欧元六世- 56 - 2 SP - 2000763 AU -卢,本盟- Li Ting-Dong盟——郑Shu-Fa盟——苏盟——李盈盈,Zhi-Yong盟——刘魏盟- Yu,范盟——通用电气,Sheng-Xiang盟——邹Qian-Da盟——元,全非盟-林,沙非盟-香港,Cong-Ming盟——姚明,Xiang-Yang盟——张Xue-Jie盟——吴,丁慧盟——周郭良齐AU -侯,Wang-Heng AU -李,婷婷盟——张Ya-Li盟——张Shi-Yin AU -风扇,剑盟——张,6月盟——夏,Ning-Shao盟——陈及时诊断严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染是治疗和预防的前提。抗体检测对RNA检测的血清学特征及补体诊断价值有待论证。方法收集浙江大学第一附属医院80例经pcr确诊的2019冠状病毒病(COVID-19)患者的系列血清。检测了抗SARS-CoV-2的总抗体(Ab)、IgM和IgG抗体，并描述了感染过程中的抗体动态。结果血清抗体、IgM和IgG转阴率分别为98.8%、93.8%和93.8%。第一个可检测的血清学标记是Ab，其次是IgM和IgG，中位血清转化时间分别为暴露后15、18和20天(d.p.e)或发病后9、10和12天(d.p.o)。抗体水平从6d.p.o开始迅速上升。并且伴随着病毒载量的下降。在疾病早期(0 ~ 7日龄)，Ab的敏感性最高(64.1%)，IgM和IgG均为33.3%; p<0.001). The sensitivities of Ab, IgM and IgG increased to 100%, 96.7% and 93.3%, respectively, 2 weeks later. When the same antibody type was detected, no significant difference was observed between enzyme-linked immunosorbent assays and other forms of immunoassays.Conclusions A typical acute antibody response is induced during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic-specific diagnosis and helpful information to evaluate the adapted immunity status of patients.Antibody responses were induced after SARS-CoV-2 infection, and the complementary diagnostic value of the antibody test to the RNA test was observed. Antibody tests are critical to the clinical management and control of SARS-CoV-2 infection and COVID-19. https://bit.ly/3fQZwZp ER -