TY -的T1 SARS-Co的血清学特征V-2 infection after exposure and post-symptom onset JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00763-2020 VL - 56 IS - 2 SP - 2000763 AU - Lou, Bin AU - Li, Ting-Dong AU - Zheng, Shu-Fa AU - Su, Ying-Ying AU - Li, Zhi-Yong AU - Liu, Wei AU - Yu, Fei AU - Ge, Sheng-Xiang AU - Zou, Qian-Da AU - Yuan, Quan AU - Lin, Sha AU - Hong, Cong-Ming AU - Yao, Xiang-Yang AU - Zhang, Xue-Jie AU - Wu, Ding-Hui AU - Zhou, Guo-Liang AU - Hou, Wang-Heng AU - Li, Ting-Ting AU - Zhang, Ya-Li AU - Zhang, Shi-Yin AU - Fan, Jian AU - Zhang, Jun AU - Xia, Ning-Shao AU - Chen, Yu Y1 - 2020/08/01 UR - //www.qdcxjkg.com/content/56/2/2000763.abstract N2 - Background Timely diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a prerequisite for treatment and prevention. The serology characteristics and complement diagnosis value of the antibody test to RNA test need to be demonstrated.Method Serial sera of 80 patients with PCR-confirmed coronavirus disease 2019 (COVID-19) were collected at the First Affiliated Hospital of Zhejiang University, Hangzhou, China. Total antibody (Ab), IgM and IgG antibodies against SARS-CoV-2 were detected, and the antibody dynamics during the infection were described.Results The seroconversion rates for Ab, IgM and IgG were 98.8%, 93.8% and 93.8%, respectively. The first detectible serology marker was Ab, followed by IgM and IgG, with a median seroconversion time of 15, 18 and 20 days post exposure (d.p.e.) or 9, 10 and 12 days post onset (d.p.o.), respectively. The antibody levels increased rapidly beginning at 6 d.p.o. and were accompanied by a decline in viral load. For patients in the early stage of illness (0–7 d.p.o), Ab showed the highest sensitivity (64.1%) compared with IgM and IgG (33.3% for both; p<0.001). The sensitivities of Ab, IgM and IgG increased to 100%, 96.7% and 93.3%, respectively, 2 weeks later. When the same antibody type was detected, no significant difference was observed between enzyme-linked immunosorbent assays and other forms of immunoassays.Conclusions A typical acute antibody response is induced during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic-specific diagnosis and helpful information to evaluate the adapted immunity status of patients.Antibody responses were induced after SARS-CoV-2 infection, and the complementary diagnostic value of the antibody test to the RNA test was observed. Antibody tests are critical to the clinical management and control of SARS-CoV-2 infection and COVID-19. https://bit.ly/3fQZwZp ER -