@article {Lou2000763作者={卢本和李,Ting-Dong和郑Shu-Fa和苏,和李盈盈,Zhi-Yong和刘魏和Yu,范和通用电气,Sheng-Xiang邹,Qian-Da和元,关丽珍和林,上海和香港,Cong-Ming和姚明,Xiang-Yang和张Xue-Jie和吴,丁慧周,郭良齐侯,Wang-Heng和李,婷婷和张Ya-Li、张、Shi-Yin和粉丝,剑和张,小君和夏,Ning-Shao和陈,},title = {SARS-CoV-2感染暴露和post-symptom后出现的血清学特征},体积= {56}= {2},elocation-id = {2000763} = {2020}, doi ={10.1183/13993003.00763 -2020},出版商={欧洲呼吸学会},188bet官网地址背景及时诊断严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染是治疗和预防的前提。抗体检测对RNA检测的血清学特征及补体诊断价值有待论证。方法收集浙江大学第一附属医院80例经pcr确诊的2019冠状病毒病(COVID-19)患者的系列血清。检测了抗SARS-CoV-2的总抗体(Ab)、IgM和IgG抗体，并描述了感染过程中的抗体动态。结果血清抗体、IgM、IgG转阴率分别为98.8%、93.8%、93.8%。第一个可检测的血清学标记是Ab，其次是IgM和IgG，中位血清转化时间分别为暴露后15、18和20天(d.p.e)或发病后9、10和12天(d.p.o)。抗体水平在第6天开始迅速上升，同时伴随着病毒载量的下降。对于早期(0{\textendash}7 d.p.o)的患者，Ab的敏感性最高(64.1\%)，而IgM和IgG的敏感性最高(33.3%);p < 0.001)。 The sensitivities of Ab, IgM and IgG increased to 100\%, 96.7\% and 93.3\%, respectively, 2 weeks later. When the same antibody type was detected, no significant difference was observed between enzyme-linked immunosorbent assays and other forms of immunoassays.Conclusions A typical acute antibody response is induced during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic-specific diagnosis and helpful information to evaluate the adapted immunity status of patients.Antibody responses were induced after SARS-CoV-2 infection, and the complementary diagnostic value of the antibody test to the RNA test was observed. Antibody tests are critical to the clinical management and control of SARS-CoV-2 infection and COVID-19. https://bit.ly/3fQZwZp}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/56/2/2000763}, eprint = {//www.qdcxjkg.com/content/56/2/2000763.full.pdf}, journal = {European Respiratory Journal} }