TY -的T1 SARS-CoV-2-spe的明显特征cific IgA response in COVID-19 patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01526-2020 VL - 56 IS - 2 SP - 2001526 AU - Yu, Hai-qiong AU - Sun, Bao-qing AU - Fang, Zhang-fu AU - Zhao, Jin-cun AU - Liu, Xiao-yu AU - Li, Yi-min AU - Sun, Xi-zhuo AU - Liang, Hong-feng AU - Zhong, Bei AU - Huang, Zhi-feng AU - Zheng, Pei-yan AU - Tian, Li-feng AU - Qu, Hui-Qi AU - Liu, De-chen AU - Wang, Er-yi AU - Xiao, Xiao-jun AU - Li, Shi-yue AU - Ye, Feng AU - Guan, Li AU - Hu, Dong-sheng AU - Hakonarson, Hakon AU - Liu, Zhi-gang AU - Zhong, Nan-shan Y1 - 2020/08/01 UR - //www.qdcxjkg.com/content/56/2/2001526.abstract N2 - In comparison to severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2 appears to be more contagious [1], and coronavirus disease 2019 (COVID-19) patients demonstrate varied clinical manifestations distinct from those seen in patients with SARS-CoV and Middle East respiratory syndrome coronavirus infections [2]. Collective results from the clinical and epidemiological observations suggest a distinct viral–host interaction in COVID-19 patients. Profiling of the antibody response during SARS-CoV-2 infection may help improve our understanding of the viral–host interaction and the immunopathological mechanisms of the disease.Humoral immune response to SARS-CoV-2 showed an early response of IgA, instead of IgM, in COVID-19 patients. As highlighted by this study, enhanced IgA responses observed in severe COVID-19 might confer damaging effects in severe COVID-19. https://bit.ly/3fA7c1IWe thank all the patients and their families involved in this study, as well as doctors, nurses and civilians that had worked hard to fight against SARS-CoV-2. We would like to express great thankfulness to Professor Shau-Ku Huang (National Health Research Institutes, Miaoli, Taiwan) for his suggestions and critical reading of this manuscript. ER -