东亚人跨性别和绝经状态的睡眠呼吸障碍和代谢共病:Nagahama研究摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 1902251 10.1183/13993003.02251 -188bet官网地址2019签证官56 2 A1松本,武A1 Murase, Kimihiko A1 Tabara, Yasuharu A1南城,佐藤A1 Kanai, Osamu A1 Takeyama, Hirofumi A1高桥,Naomi A1岩漠Satoshi A1 Tanizawa Kiminobu A1 Wakamura,Tomoko A1 Komenami, Naoko A1 Setoh, Kazuya A1 Kawaguchi, Takahisa A1 Tsutsumi, Takanobu A1 Morita, Satoshi A1 Takahashi, Yoshimitsu A1 Nakayama, Takeo A1 Hirai, Toyohiro A1 Matsuda, Fumihiko A1 Chin，众所周知，肥胖或代谢性共病患者的睡眠呼吸障碍(SDB)患病率增加。然而，根据肥胖的严重程度，SDB的患病率与共病相关的增长方式仍不清楚。本横断面研究评估了7713名社区参与者≥2夜血氧测定。通过腕关节活动记录仪(actiodi3%)获得的睡眠持续时间校正后的3%氧饱和度指数来评估SDB。SDB严重程度由actin - odi3%定义。肥胖定义为体重指数≥25 kg·m−2。正常、轻度、中度和重度SDB的患病率分别为41.0% (95% CI 39.9 ~ 42.1%)、46.9%(45.8 ~ 48.0%)、10.1%(9.5 ~ 10.8%)和2.0%(1.7 ~ 2.3%)，性别差异显著(男性>绝经后女性>绝经前女性)。高血压、糖尿病和代谢综合征等合并症与中到重度SDB的患病率独立相关，其中任何一种与肥胖的巧合与中到重度SDB的高概率相关(高血压OR 8.2, 95% CI 6.6-10.2; diabetes OR 7.8, 95% CI 5.6–10.9; metabolic syndrome OR 6.7, 95% CI 5.2–8.6). Dyslipidaemia in addition to obesity was not additively associated with the prevalence of moderate-to-severe SDB. The number of antihypertensive drugs was associated with SDB (p for trend <0.001). Proportion of a high cumulative percentage of sleep time with oxygen saturation measured by pulse oximetry <90% increased, even among moderate-to-severe SDB with increases in obesity.Metabolic comorbidities contribute to SDB regardless of the degree of obesity. We should recognise the extremely high prevalence of moderate-to-severe SDB in patients with obesity and metabolic comorbidities.Metabolic comorbidities (hypertension, diabetes, dyslipidaemia, metabolic syndrome) contribute to SDB regardless of obesity grade. We should recognise the extremely high prevalence of moderate–severe SDB in patients with obesity and metabolic comorbidities. https://bit.ly/3586fJg