TY -的T1 -自身免疫性疾病的主要遗传因素与自身抗体的存在在过敏性肺炎JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01380 -2019欧元六世- 56 - 2 SP - 1901380 AU Ivette Buendia-Roldan AU -路易斯Santiago-Ruiz盟Gloria Perez-Rubio AU - Mayra Mejia盟Jorge Rojas-Serrano AU -恩里克Ambrocio-Ortiz AU -吉奥瓦尼Benitez-Valdez盟盟莫伊塞斯塞尔曼说-兰姆克Falfan-Valencia Y1 - 2020/08/01 UR - //www.qdcxjkg.com/content/56/2/1901380.abstract N2 -背景过敏性肺炎是一种免疫介导性疾病引发的感染人群的暴露于有机粒子。据报道,一群患者的过敏性肺炎发展自身抗体有或没有临床表现的自身免疫性疾病。然而,参与这个过程的机制和自身抗体的效果在过敏性肺炎的临床过程是未知的。我们评估之间的联系人类白细胞抗原(HLA)二类等位基因和过敏性肺炎患者,没有自身抗体。方法对170包括过敏性肺炎患者。我们分析了抗核抗体的存在,类风湿因子,anti-SSA / Ro anti-SSB / La和anti-CCP时诊断。此外,在病人的一个子集,我们评估反sci - 70, anti-neutrophil胞质抗体,anti-DNA。HLA打字都使用PCR sequence-specific引物在高分辨率模式,包括HLA-DRB1和HLA-DQB1位点。采用Epi-Info v7和SPSS v20执行统计分析。60过敏性肺炎患者结果显示血清自身抗体(HPAbs +),和110年过敏性肺炎病人没有(HPAbs−)。等位基因的频率HLA-DRB1 * 03:01 HPAbs +组显著增加(分别为10.8%和0.45%; OR 30.14, 95% CI 3.83–237.1; p=1.65×10-4 after Bonferroni's correction). Likewise, we found that the haplotype DRB1*03:01-DQB1*02:01, which is part of the 8.1 ancestral haplotype, a major genetic determinant of autoimmune diseases, confers significant risk to develop autoantibodies (OR 19.23, 95% CI 2.37–155.9; p=0.0088 after Bonferroni's correction). In addition, the HLA-DRB1*03:01 allele was associated with higher mortality in patients with hypersensitivity pneumonitis (adjusted OR 5.9, 95% CI 1.05–33.05; p=0.043).Conclusions A subset of hypersensitivity pneumonitis patients presents circulating autoantibodies and higher mortality that are associated with some alleles of 8.1 ancestral haplotype.Alleles from 8.1 ancestral haplotype (#HLA-DRB1 and DQB1 loci) are associated with #autoantibodies production in #hypersensitivity #pneumonitis in a cohort of Mexican mestizo patients https://bit.ly/3bprPeB ER -