%0期刊文章%A Buendía-Roldán, Ivette %A Santiago-Ruiz, Luis %A Pérez-Rubio, Gloria %A Mejía, Mayra %A Rojas-Serrano, Jorge %A Ambrocio-Ortiz, Enrique %A Benítez-Valdez, Geovanni %A Selman, Moisés %A Falfán-Valencia，Ramcés %T自身免疫性疾病的一个主要遗传决定因素与超敏性肺炎中自身抗体的存在有关%D 2020 %R 10.1183/13993003.01380-2019 J欧洲呼吸杂志P 1901380% V 56% N 2% X背景超敏性肺炎是一种由易感个体暴露于有机颗粒引发的免疫介导疾病。据报道，过敏性肺炎患者的一个亚组出现自身抗体，有或没有自身免疫性疾病的临床表现。然而，这一过程的机制以及自身抗体对超敏性肺炎临床病程的影响尚不清楚。我们评估了人类白细胞抗原(HLA) II类等位基因与有和没有自身抗体的超敏性肺炎患者之间的关系。方法对170例超敏性肺炎患者进行分析。我们分析了诊断时抗核抗体、类风湿因子、抗ssa /Ro、抗ssb /La和抗ccp的存在。此外，在一部分患者中，我们评估了抗scl -70、抗中性粒细胞细胞质抗体和抗dna。采用高分辨率PCR序列特异性引物进行HLA分型，包括HLA- drb1和HLA- dqb1位点。采用Epi-Info v7和SPSS v20进行统计分析。结果60例超敏性肺炎患者血清自身抗体(HPAbs+)， 110例超敏性肺炎患者血清自身抗体(HPAbs−)。 The frequency of the allele HLA-DRB1*03:01 was remarkably increased in the HPAbs+ group (10.8% versus 0.45%; OR 30.14, 95% CI 3.83–237.1; p=1.65×10-4 after Bonferroni's correction). Likewise, we found that the haplotype DRB1*03:01-DQB1*02:01, which is part of the 8.1 ancestral haplotype, a major genetic determinant of autoimmune diseases, confers significant risk to develop autoantibodies (OR 19.23, 95% CI 2.37–155.9; p=0.0088 after Bonferroni's correction). In addition, the HLA-DRB1*03:01 allele was associated with higher mortality in patients with hypersensitivity pneumonitis (adjusted OR 5.9, 95% CI 1.05–33.05; p=0.043).Conclusions A subset of hypersensitivity pneumonitis patients presents circulating autoantibodies and higher mortality that are associated with some alleles of 8.1 ancestral haplotype.Alleles from 8.1 ancestral haplotype (#HLA-DRB1 and DQB1 loci) are associated with #autoantibodies production in #hypersensitivity #pneumonitis in a cohort of Mexican mestizo patients https://bit.ly/3bprPeB %U //www.qdcxjkg.com/content/erj/56/2/1901380.full.pdf