AU - Adderley, Nicola AU - Humphreys, Christopher J. AU - Barnes, Hayley AU - Ley, Brett AU - Premji, Zahra A. AU - Johannson, Kerri A. TI -慢性超敏性肺炎支气管肺泡灌洗液淋巴细胞增生:系统回顾和荟萃分析援助- 10.1183/13993003.00206 -2020 DP - 2020年8月01 TA -欧洲呼吸杂志》第六PG - 2000206 - 56 IP - 2 4099 - //www.qdcxjkg.com/content/56/2/2000206.short 4100 - //www.qdcxjkg.com/content/56/2/2000206.full所以欧元和J2020 8月01;支气管肺泡灌洗液(BALF)淋巴细胞百分比在慢性超敏性肺炎(CHP)诊断中的作用尚不清楚。我们对支气管肺泡灌洗(BAL)淋巴细胞百分比在CHP诊断中的作用进行了系统回顾和meta分析。方法检索Medline、Embase和Cochrane图书馆从成立到2019年8月。获取患者个体数据，以测试不同阈值下BAL淋巴细胞百分比的性能特征。采用随机效应模型进行合并估计，并对CHP和非CHP间质性肺病(ILDs)进行比较。结果系统评价纳入53项研究，meta分析纳入42项研究。原发性肺纤维化(IPF)患者BAL淋巴细胞百分比为10.0% (95% CI 6.9-13.1, I2=91.2%)，非IPF特发性间质性肺炎(IIP)患者BAL淋巴细胞百分比为23.1% (95% CI 3.0-43.2, I2=85.2%)， 23.4% (95% CI 11.0-35.9, I2=85.2%)。I2=45.7%)，结节病31.2% (95% CI 17.6-44.8, I2=95.2%)。CHP和IPF (p lt;0.0001)、非IPF IIP (p=0.0309)或CTD-ILD (p=0.0824)之间的结果不同，但CHP和结节病之间没有差异(p=0.0966)。使用来自8项研究的单个患者数据，淋巴细胞百分比阈值为>20%对CHP的敏感性为68.1%，特异性为64.8%。 Higher thresholds provided lower sensitivity with higher specificity. Older age and ever having smoked were associated with lower lymphocyte percentage in CHP.Conclusions BAL lymphocyte percentage is higher in CHP compared to IPF and other IIPs, with higher thresholds providing improved specificity at the cost of sensitivity. However, the parent studies are at risk of incorporation bias and prospective studies should evaluate the additive discriminate value of BAL lymphocyte percentage to accurately diagnose CHP.BALF lymphocyte percentage is higher in patients with #CHP compared to #IPF, #IIP and #CTD-ILD, but studies available to fully address this question are limited in scope #AdvancesinILD https://bit.ly/2RntTMr