RT期刊论文SR电子T1的空气污染和哮喘的从出生到成年早期JF欧洲呼吸杂志JO欧元呼吸杂志FD欧洲呼吸学会SP发展2000147 DO 10.1183 / 13993003.00147-2020 VO 56 1 A1 Gehring集团，乌尔里克A1 Wijga，ALET188bet官网地址H. A1的Koppelman，杰拉德H. A1 Vonk，朱迪M. A1斯密特，亨丽埃特A. A1 Brunekreef，伯特YR 2020 UL //www.qdcxjkg.com/content/56/1/2000147.abstract AB背景空气污染与儿童及成人哮喘的发展有关，但是从青春期到成年的过渡期间，对哮喘发展的影响目前还不清楚。成人的研究缺乏历史暴露在生命的不同时期因此无法评估暴露的相关性。我们评估了早期的生活和更近的空气污染暴露哮喘发展的相关性，从出生到早期adulthood.Methods我们使用的荷兰人准PIAMA的3687名参与者（预防哮喘和螨过敏的发病率）出生队列和链接数据哮喘incidence until age 20 years to estimated concentrations of nitrogen dioxide (NO2), particulate matter with a diameter <2.5 μm (PM2.5), <10 μm (PM10), and 2.5–10 μm, and PM2.5 absorbance (“soot”) at the residential address. We assessed overall and age-specific associations with air pollution exposure with discrete time-hazard models, adjusting for potential confounders.Results Overall, we found higher incidence of asthma until the age of 20 years with higher exposure to all pollutants at the birth address (adjusted odds ratio (95% CI) ranging from 1.09 (1.01–1.18) for PM10 to 1.20 (1.10–1.32) for NO2) per interquartile range increase) that were rather persistent with age. Similar associations were observed with more recent exposure defined as exposure at the current home address. In two-pollutant models with particulate matter, associations with NO2 persisted.Conclusions Exposure to air pollution, especially from motorised traffic, early in life may have long-term consequences for asthma development, as it is associated with an increased risk of developing asthma through childhood and adolescence into early adulthood.Early-life exposure to air pollution, especially from motorised traffic, may have long-term consequences for asthma development, as it is associated with an increased risk of developing asthma through childhood and adolescence into early adulthood https://bit.ly/39uZHVH