AU - Gehring, Ulrike AU - Wijga, Alet H. AU - Koppelman, Gerard H. AU - Vonk, Judith M. AU - Smit, Henriette A. AU - Brunekreef，伯特TI -空气污染和哮喘从出生到成年早期的发展援助- 10.1183/13993003.00147 -2020 DP - 2020年7月01 TA -欧洲呼吸杂志》第六PG - 2000147 - 56 IP - 1 4099 - //www.qdcxjkg.com/content/56/1/2000147.short 4100 - //www.qdcxjkg.com/content/56/1/2000147.full所以欧元和J2020 7月01;56 AB背景空气污染与儿童和成人的哮喘发展有关，但从青少年到成年过渡期间对哮喘发展的影响尚不清楚。成人研究缺乏历史暴露，因此不能评估暴露在不同生命阶段的相关性。我们评估了早期生活和最近的空气污染暴露与从出生到成年早期哮喘发展的相关性。方法我们使用数据的3687名参与者的潜在荷兰PIAMA(预防和哮喘的发病率和螨虫过敏)出生队列和有关哮喘发病率在20岁之前估计的二氧化氮(NO2)浓度,颗粒物直径& lt; 2.5μm (PM2.5) & lt; 10μm (PM10),和-10年2.5μm,以及居住地址的PM2.5吸光度(“烟尘”)。我们利用离散时间风险模型评估了空气污染暴露的总体和年龄特异性相关性，并对潜在混杂因素进行了调整。结果总体而言，我们发现20岁之前的哮喘发病率更高，出生时暴露于所有污染物的比例更高(调整优势比(95% CI)， PM10为1.09 (1.01-1.18)，NO2为1.20(1.10-1.32)，每四分位范围增加)，且随着年龄的增长相当持久。在最近的暴露中也观察到类似的关联，被定义为当前家庭住址的暴露。 In two-pollutant models with particulate matter, associations with NO2 persisted.Conclusions Exposure to air pollution, especially from motorised traffic, early in life may have long-term consequences for asthma development, as it is associated with an increased risk of developing asthma through childhood and adolescence into early adulthood.Early-life exposure to air pollution, especially from motorised traffic, may have long-term consequences for asthma development, as it is associated with an increased risk of developing asthma through childhood and adolescence into early adulthood https://bit.ly/39uZHVH