TY - JOUR T1 - 肺内气道平滑肌是高反应性与在哮喘JF一个独特的蛋白质组 - 欧洲呼吸杂志JO - 欧洲呼吸j执行 - 10.1183 / 13993003.02178-2019 VL - 56 - 1个SP - 1902178 AU - Ijpma，AU的Gijs -Kachmar，琳达AU - Panariti，爱丽丝AU - Matusovsky，奥列格S. AU - 托格森，达拉非盟 - 贝内代蒂，安德烈AU - LAUZON，安妮 - 玛丽Y1 - 2020年7月1日UR - //www.qdcxjkg.com/content/56/1/1902178.abstract N2 - 哮喘发作期气道缩窄是气道平滑肌（ASM）收缩的结果。虽然普遍认为ASM是哮喘hypercontractile，这并没有得到明确证实。是否气道高反应性（AHR）是增加的ASM质量的结果单独使用或也增加肌肉的收缩力产生的每单位直接决定为treatment.To的潜在途径评估ASM是否是hypercontractile我们从肺内孤立ASM执行一系列力学测量的气道，并从人体肺部trachealis。我们分析了ASM和整个呼吸道蛋白质组核实，如果蛋白质的变化有助于ASM properties.We变化报告给人类哮喘支气管肺内增加隔离ASM收缩应力，刚度具体，增加气道阻力在哮喘的网站。其他参数的收缩并没有改变。无偏质谱数据的主成分分析（PCA）表明哮喘患者的清晰聚类相对于ASM特定蛋白质。整个呼吸道蛋白质组显示结构蛋白的上调。我们没有发现在肌球蛋白的活性在哮喘ASM.In结论的调节差的证据，我们发现，ASM在肺内气道在哮喘的水平确实高反应性。 We identified several proteins that are upregulated in asthma that could contribute to hyperreactivity. Our data also suggest enhanced force transmission associated with enrichment of structural proteins in the whole airway. These findings may lead to novel directions for treatment development in asthma.Intrapulmonary, but not tracheal, airway smooth muscle is hyperreactive in asthma, together with pro-contractile changes in the airway smooth muscle proteome. Several proteins were identified that could be targeted for treatment of the hyperreactivity. http://bit.ly/33esYSU ER -