％0刊杂志文章％A garcia，Erika％A张，悦％A Rappaport，Edward B.％A Berhane，Kiros％的丝绸，Patrick％的丝绸，Philip E.％A Molshatzki，NoA％A Gilliland，Frank D.％A ECKEL，Sandrah P.％T indraltren的extrate in呼出的一氧化氮轨迹，7年期间％d 2020％R 10.1183 / 13993003.00011-2020％J欧洲呼吸期轴颈％p 2000011％v 56％n 1％X分数呼出的一氧化氮（FENO50），过敏气道炎症的标志物用于呼吸研究和哮喘临床护理;然而，在童年期间随着年龄增长的轨迹并未得到很好的表征。我们在重要的躯体增长期间纵向检查了FENO50，以描述儿童期和健康参与者的青春期的轨迹，并评估临床因素作为轨迹的潜在决定因素。在六次访问中，在1791个学童的人口群组中收集六次访问。没有哮喘（入口8.4岁的中位年龄）。使用广义添加剂混合模型估计平滑的性别特定的FENO50轨迹，参与者级随机效应。我们评估了性别特异性轨迹是否受种族/种族，体重指数（BMI）百分点，过敏性鼻炎或青春期的影响。在后期的儿童时期观察到不同的FENO50模式，并且有几个因素与FENO50水平或FENO50的变化有关作为参与者。FENO50年龄轨迹与年龄相似，直到年龄~11.5岁，之后雄性比女性更大的FENO50变化。Feno50-yse曲目中的这种分歧与青春期一致。 Males with higher starting BMI percentile had attenuated FENO50–age slopes. Among males, FENO50 levels were lower in non-Hispanic white subjects. Among both sexes, participants with rhinitis had higher FENO50. FENO50 levels within individuals tracked over time; however, there was considerable variation in FENO50 patterns across participants.FENO50 trajectories from longitudinal data provide evidence of sex differences coinciding with puberty, suggesting potential hormone link. Improved understanding of determinants of FENO50 trajectories is needed to realise the potential for using individualised predicted FENO50 trajectories.Longitudinal FENO50 trajectories in healthy children aged 8–16 years displayed a similar upward trend in males and females until age 11.5, after which males had higher FENO50. Males with higher starting BMI percentile had attenuated FENO50 slopes with age. https://bit.ly/2UMb8mI %U //www.qdcxjkg.com/content/erj/56/1/2000011.full.pdf