@article {Garcia2000011作者={加西亚,埃里卡和张曰Rappaport,爱德华·b·博,Kiros某个,帕特里克Silkoff, Philip e . Molshatzki,诺亚和Gilliland,弗兰克·d·埃克尔,Sandrah p}, title ={呼出一氧化氮轨迹模式和决定因素的学生在7年时间内},体积= {56},分数型呼出性一氧化氮(FENO50)是过敏性气道炎症的标志物，用于呼吸系统研究和哮喘临床护理;188bet官网地址然而，它在儿童时期随着年龄增长的轨迹还没有被很好地描述。我们在一个重要的身体生长时期纵向检查FENO50，以描述健康参与者的童年和青少年的轨迹，并评估临床因素作为轨迹的潜在决定因素。在1791名无哮喘学童(入组时中位年龄为8.4岁)的人群队列中，在8年多的6次随访中收集FENO50。平滑的性别特异性FENO50轨迹使用广义相加混合模型进行估计，具有参与者水平的随机效应。我们评估了性别特异性轨迹是否受种族/民族、身体质量指数(BMI)百分位数、变应性鼻炎或青春期的影响。不同性别在儿童后期观察到不同的FENO50模式，一些因素与FENO50水平或随着年龄增长的FENO50变化相关。FENO50的年龄轨迹在11.5岁之前与性别相似，之后雄性FENO50的变化大于雌性。FENO50年龄轨迹上的这种分歧与青春期是一致的。BMI起始百分位数较高的男性FENO50的年龄斜率较小。 Among males, FENO50 levels were lower in non-Hispanic white subjects. Among both sexes, participants with rhinitis had higher FENO50. FENO50 levels within individuals tracked over time; however, there was considerable variation in FENO50 patterns across participants.FENO50 trajectories from longitudinal data provide evidence of sex differences coinciding with puberty, suggesting potential hormone link. Improved understanding of determinants of FENO50 trajectories is needed to realise the potential for using individualised predicted FENO50 trajectories.Longitudinal FENO50 trajectories in healthy children aged 8{\textendash}16 years displayed a similar upward trend in males and females until age 11.5, after which males had higher FENO50. Males with higher starting BMI percentile had attenuated FENO50 slopes with age. https://bit.ly/2UMb8mI}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/56/1/2000011}, eprint = {//www.qdcxjkg.com/content/56/1/2000011.full.pdf}, journal = {European Respiratory Journal} }