TY -的T1 -慢性血栓栓塞的诊断pulmonary hypertension after acute pulmonary embolism JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00189-2020 VL - 55 IS - 6 SP - 2000189 AU - Klok, Fredrikus A. AU - Couturaud, Francis AU - Delcroix, Marion AU - Humbert, Marc Y1 - 2020/06/01 UR - //www.qdcxjkg.com/content/55/6/2000189.abstract N2 - Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long-term complication of acute pulmonary embolism (PE). Untreated CTEPH is fatal, but, if diagnosed in time, successful surgical (pulmonary endarterectomy), medical (pulmonary hypertension drugs) and/or interventional (balloon pulmonary angioplasty) therapies have been shown to improve clinical outcomes, especially in case of successful pulmonary endarterectomy. Early diagnosis has however been demonstrated to be challenging. Poor awareness of the disease by patients and physicians, high prevalence of the post-PE syndrome (i.e. persistent dyspnoea, functional limitations and/or decreased quality of life following an acute PE diagnosis), lack of clear guideline recommendations as well as inefficient application of diagnostic tests in clinical practice lead to a reported staggering diagnostic delay >1 year. Hence, there is a great need to improve current clinical practice and diagnose CTEPH earlier. In this review, we will focus on the clinical presentation of and risk factors for CTEPH, and provide best practices for PE follow-up programmes from expert centres, based on a clinical case.Improving education of PE caretakers, higher awareness for CTEPH and further validation and implementation of clinical/radiological algorithms for earlier CTEPH diagnosis will help ensure earlier referral to expert centres and improved prognosis http://bit.ly/2Qb9jOt ER -