TY -的T1 -胶原IV:新startin至关重要g point for engineering upper airways JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01130-2020 VL - 55 IS - 6 SP - 2001130 AU - De Santis, Martina M. AU - Wagner, Darcy E. Y1 - 2020/06/01 UR - //www.qdcxjkg.com/content/55/6/2001130.abstract N2 - Half a century has passed since the discovery of collagen IV in 1966 by Kefalides [1]. Collagen IV is the main collagen component of the basement membrane in many organs, including the lung and trachea. It is a network-forming collagen that underlies epithelial and endothelial cells and serves a crucial role in forming barriers between tissue compartments [2, 3]. Mature collagen IV is a heterotrimer comprised from a combination of two or three of the six known collagen IV alpha chains which are increasingly recognised as being tissue- and organ-specific. Integrin α2 is a known cellular receptor for attachment to collagen IV and through interactions with different binding partners, influences cell adhesion, migration and polarity [4].Collagen IV and integrin alpha 2 engagement is critical for forming differentiated airway epithelium capable of mucociliary clearance in vitro, but pre-vascularised scaffolds transplanted under immunosuppresion fail to maintain differentiated epithelium https://bit.ly/2wT9XK5 ER -