T1 -母亲在怀孕期间吸烟影响子女成年后哮喘发作:后续从出生到46岁JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01857 -2019欧元六世- 55 - 6 SP - 1901857 AU Toppila-Salmi桑娜AU - Luukkainen,安妮卡·t·盟——徐Baizhuang盟,兰皮雅斯盟——奥维宁的,受到Juha盟——Dhaygude基肖尔盟——Jarvelin Marjo-Riitta AU - Pekkanen,摘要N2 -基本原理环境烟草烟雾(ETS)暴露增加儿童哮喘风险。关于成人哮喘的产前检查的知识是有限的。目的探讨产前哮喘与成人哮喘发病的关系。1966年芬兰北部出生队列研究纳入了5200人的问卷调查和临床数据，这些人31岁前没有医生诊断的哮喘。孕妇妊娠最后3个月吸烟与医生诊断的哮喘发作和成年后代肺功能之间的关系采用调整后的多元回归分析进行研究。31岁至46岁之间经医生诊断的哮喘累积发病率男性为5.1%，女性为8.8%。妊娠期烟雾暴露与子代成人发病哮喘相关(校正或1.54,95% CI 1.04-2.29)，即在报告既往未诊断哮喘(9.63,95% CI 2.28-40.67)或既往咳嗽伴有喘息(3.21,95% CI 1.71-6.05)的子代中。在妊娠期暴露于烟雾与31岁时子代的用力呼气量(FEV1)/用力肺活量(FVC)比率之间发现了显著的相关性。 In offspring with the haplotype rs11702779-AA of RUNX1, gestational smoke exposure was associated with adult-onset asthma (5.53, 95% CI 2.11–14.52, adjusted p-value for interaction 0.10).Conclusion Maternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects.Maternal smoking during pregnancy is linked to cumulative incidence of asthma in offspring between 31 and 46 years. The association was accentuated in those reporting at age 31 as having past respiratory problems and/or who had haplotype rs11702779-AA. http://bit.ly/2WgR91H ER -