妊娠期母亲吸烟影响子女成年后哮喘发作:后续从出生到46岁摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 1901857 10.1183/13993003.01857 -2019签证官55是6 A1 Toppil188bet官网地址a-Salmi,桑娜A1 Luukkainen,安妮卡·t·A1徐,Baizhuang A1兰皮,总裁A1奥维宁的,受到Juha A1 Dhaygude,基肖尔A1 Jarvelin, Marjo-Riitta A1 Pekkanen,胡年2020 UL //www.qdcxjkg.com/content/55/6/1901857.abstract AB理由接触环境烟草烟雾(ETS)增加儿童哮喘的风险。关于成人哮喘的产前检查的知识是有限的。目的探讨产前哮喘与成人哮喘发病的关系。1966年芬兰北部出生队列研究纳入了5200人的问卷调查和临床数据，这些人31岁前没有医生诊断的哮喘。孕妇妊娠最后3个月吸烟与医生诊断的哮喘发作和成年后代肺功能之间的关系采用调整后的多元回归分析进行研究。31岁至46岁之间经医生诊断的哮喘累积发病率男性为5.1%，女性为8.8%。妊娠期烟雾暴露与子代成人发病哮喘相关(校正或1.54,95% CI 1.04-2.29)，即在报告既往未诊断哮喘(9.63,95% CI 2.28-40.67)或既往咳嗽伴有喘息(3.21,95% CI 1.71-6.05)的子代中。在妊娠期暴露于烟雾与31岁时子代的用力呼气量(FEV1)/用力肺活量(FVC)比率之间发现了显著的相关性。在RUNX1单倍型rs11702779-AA的后代中，妊娠期烟雾暴露与成年期哮喘相关(5.53,95% CI 2.11-14.52，调整p值交互作用为0.10)。结论妊娠期间母体吸烟与31 ~ 46岁子代哮喘累积发病率有关。 The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects.Maternal smoking during pregnancy is linked to cumulative incidence of asthma in offspring between 31 and 46 years. The association was accentuated in those reporting at age 31 as having past respiratory problems and/or who had haplotype rs11702779-AA. http://bit.ly/2WgR91H