ty -jour t1-怀孕期间的孕产妇吸烟会影响后代的成年哮喘发作：从出生到46岁的后续哮喘 - 欧洲呼吸杂志JO -EUR EUR RESSIR J DO -10.1183/13993003.01857-2019-2019 vl -55- 1901857 AU - Toppila-Salmi, Sanna AU - Luukkainen, Annika T. AU - Xu, Baizhuang AU - Lampi, Jussi AU - Auvinen, Juha AU - Dhaygude, Kishor AU - Järvelin, Marjo-Riitta AU - Pekkanen, Juha Y1 -2020/06/01 ur -http：//www.qdcxjkg.com/content/55/6/6/1901857.Abstract N2-基本原理环境烟草烟雾（ETS）暴露会增加儿童的哮喘风险。对成人哮喘的产前ETS的了解有限，可以确定产前ETS与成人哮喘之间的关联。测量和主要结果是5200人的问卷和临床数据，没有医生 - 诊断哮喘的医生 - 诊断31岁。，使用了1966年北部芬兰出生队列的研究。使用调整后的多元回归分析，研究了怀孕的最后三个月在怀孕的最后3个月与成人后代的肺功能和肺功能的关联。男性诊断为31至46岁的医师诊断哮喘的累积发生率为5.1％，女性为8.8％。妊娠烟雾暴露与后代（调整后的或1.54，95％CI 1.04-2.29）中的成人发作哮喘有关，即在报道过去未诊断哮喘的后代中（或9.63，95％CI 2.28-40.67）或过去的CI 2.28-40.67）喘息（3.21，95％CI 1.71–6.05）。在31岁的1 s（FEV1）/强制生命力（FVC）比后，后代烟雾暴露与后代的强迫呼气量之间发现了显着关联。在带有Runx1的单倍型RS11702779-AA的后代中，妊娠烟雾暴露与成人发作的哮喘有关（5.53，95％CI 2.11-14.52，调整后的P值，相互作用0.10）。 incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects.Maternal smoking during pregnancy is linked to cumulative incidence of asthma in offspring between 31 and 46 years. The association was accentuated in those reporting at age 31 as having past respiratory problems and/or who had haplotype rs11702779-AA. http://bit.ly/2WgR91H ER -