TY-JUR T1 - 妊娠期间的孕产妇吸烟会影响成人的后代哮喘发病：从出生46岁开始的后续工作JF - 欧洲呼吸期刊JO - EUR RESPIR J DO - 10.1183 / 13993003.01857-2019 VL - 55 IS - 6 SP- 1901857 Au - Toppila-Salmi，Sanna Au - Luukkainen，Annika T. Au - 徐，Baizhuang Au - Lampi，Jussi Au - Auvinen，Juha Au - Dhaygude，Kishor Au - Järvelin，Marjo-Riitta Au - Pekkanen，Juha Y1 -2020/06/01 UR - //www.qdcxjkg.com/content/55/6/1901857.Abstract n2 - 理由环境烟草烟雾（ETS）曝光会增加儿童的哮喘风险。对成人发病哮喘的产前ETS有限的了解。目的，确定产前ETS和成人发病哮喘之间的关联。和主要结果5200人的问卷和临床资料，31岁，没有医生诊断的哮喘被纳入芬兰北部出生队列1966年的研究。使用调整后的多变量回归分析研究了妊娠期妊娠期妊娠期妊娠早期和成人后代肺功能的妊娠期孕妇吸烟协会。在31至46岁之间的医生诊断的哮喘患者的累积发病率为5.1％，妇女中的8.8％。妊娠烟雾暴露在后代（调整或1.54,95％CI 1.04-29）中与成人发作的哮喘有关，即在报告过去未诊断的哮喘（或9.63,95％CI 2.28-40.67）或过去咳嗽中的后代喘息（3.21,95％CI 1.71-6.05）。在妊娠烟雾暴露和后代在31岁之间的妊娠烟雾暴露和后代的强制呼气量（FVC）比率之间检测到显着的关联。在Haplotype RS11702779-AA的后代，妊娠烟暴露与成人发作哮喘有关（5.53,95％CI 2.11-14.52，调整后的相互作用的p值0.10）。怀孕期间的母亲吸烟与累积有关 incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects.Maternal smoking during pregnancy is linked to cumulative incidence of asthma in offspring between 31 and 46 years. The association was accentuated in those reporting at age 31 as having past respiratory problems and/or who had haplotype rs11702779-AA. http://bit.ly/2WgR91H ER -