@article {Toppila-Salmi1901857，作者= {Toppila-萨尔米，Sanna的和Luukkainen，安妮卡T.和许，白庄和兰皮，尤西和Auvinen，尤哈和Dhaygude，基肖尔和J {\“一个} rvelin，玛乔-丽塔和Pekkanen，尤哈}，标题= {产妇在怀孕期间吸烟会影响后代哮喘的成人发病：从出生的后续年龄46岁}，体积= {55}，数量= {6}，elocation-ID = {1901857}，年= {} 2020，DOI = {10.1183 / 13993003.01857-2019}，出版商= {欧洲呼吸学会}，抽象=188bet官网地址 {理环境烟草烟雾（ETS）暴露的增加儿童哮喘的风险。有产前ETS的知识有限成人发病asthma.Objectives为了确定产前ETS和成年发病asthma.Measurements和主要成果问卷和5200人的临床数据，31岁，谁被列入芬兰北部无医师诊断为哮喘之间的关联出生队列研究1966年使用。母亲吸烟的关联期间采用调整多元回归分析，最后3个月的怀孕与医生诊断的哮喘发作，并与成年子女的肺功能进行了研究。31和46岁的医师诊断为哮喘的累计发生率为5.1 \男性％和妇女8.8 \％。妊娠期烟雾暴露与子代之间的成人哮喘（调整OR 1.54，95 \％CI 1.04 {\ textendash} 2.29），后代中即谁报告无论是过去的非诊断的哮喘（OR 9.63，95 \％CI 2.28 {相关\ textendash} 40.67）或过去咳嗽与喘鸣（3.21，95 \％CI 1.71 {\ textendash} 6.05）。妊娠烟雾暴露和后代之间检测到显著关联{\ textquoteright}š用力呼气容积1秒（FEV1）31岁/用力肺活量（FVC）的比率。与RUNX1的单倍型rs11702779-AA的后代，妊娠烟雾暴露与成人发作哮喘有关（5.53，95 \％CI 2.11 {\ textendash} 14.52，调整后的相互作用0.10 p值）在怀孕期间。结论母亲吸烟是 associated with the cumulative incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring{\textquoteright}s airways to ETS and its putative long-term effects.Maternal smoking during pregnancy is linked to cumulative incidence of asthma in offspring between 31 and 46 years. The association was accentuated in those reporting at age 31 as having past respiratory problems and/or who had haplotype rs11702779-AA. http://bit.ly/2WgR91H}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/55/6/1901857}, eprint = {//www.qdcxjkg.com/content/55/6/1901857.full.pdf}, journal = {European Respiratory Journal} }