TY - JOUR T1 -湖北(中心)和湖北以外(非中心)收治的COVID-19住院患者的临床特征和结局:全国分析中国摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.00562 -2020欧元六世- 55 - 6 SP - 2000562 AU -梁,文非盟-关,Wei-jie AU - Li Cai-chen AU - Li Yi-min盟——梁、Heng-rui盟——赵,易盟——刘Xiao-qing盟——唱,凌AU - Chen Ru-chong AU - Tang春丽AU -王,道盟- Wang Wei盟——他,Qi-hua AU - Chen Zi-sheng AU - Wong Sook-San盟——Zanin马克盟——刘,君非盟-徐,鑫盟——黄,小君非盟- Li Jian-fu盟——或者,李敏AU - Cheng博盟——熊,掸族盟——谢Zhan-hong AU - Ni Zheng-yi盟——胡余盟——刘,Lei盟——山,香港非盟- Lei, Chun-liang盟——彭Yi-xiang盟——魏、李盟——刘永盟——胡Ya-hua盟——彭,彭AU -王,Jian-ming盟——刘Ji-yang盟——陈,中盟-李,帮派盟——郑Zhi-jian盟——秋,Shao-qin AU -罗,杰盟——你们,长江三峡盟——朱Shao-yong AU - Cheng Lin-ling盟——你们冯AU - Li Shi-yue AU -郑,《金瓶梅盟——张Nuo-fu盟——钟,南山盟——他,Jian-xing Y1 - 2020/06/01 UR - //www.qdcxjkg.com/content/55/6/2000562.abstract N2 -背景在2019年爆发的冠状病毒病(COVID-19)、一致和相当大的患者的疾病严重程度和死亡率的差异在湖北省相比中国其他地区曾被观察到。我们试图比较湖北省内外患者的临床特征和治疗结果，并探讨这些差异背后的因素。方法与国家卫健委合作，建立中国住院病例回顾性队列研究。比较湖北省内外患者的临床特点、重症事件发生率、死亡发生率、到达危重症(有创通气或重症监护病房住院或死亡)的时间。确定武汉相关暴露(武汉是湖北省疫情中心和行政中心，可能是湖北疫情严重的关键因素)和症状出现至入院时间对预后的影响。结果在数据截止点(2020年1月31日)，收集了来自31个省级行政区575家医院的1590例病例(核心队列)。重症病例和死亡率分别为16.0%和3.2%。湖北省647例患者(主要是武汉相关暴露患者，597例(92.3%)年龄较大(平均年龄49.7岁比44.9岁)，共病病例较多(32.9%比19.7%)，症状负担较高，放射学表现异常，特别是 a longer waiting time between symptom onset and admission (5.7 versus 4.5 days) compared with patients outside Hubei. Patients in Hubei (severe event rate 23.0% versus 11.1%, death rate 7.3% versus 0.3%, HR (95% CI) for critical illness 1.59 (1.05–2.41)) have a poorer prognosis compared with patients outside Hubei after adjusting for age and comorbidity. However, among patients outside Hubei, the duration from symptom onset to hospitalisation (mean 4.4 versus 4.7 days) and prognosis (HR (95%) 0.84 (0.40–1.80)) were similar between patients with or without Wuhan-related exposure. In the overall population, the waiting time, but neither treated in Hubei nor Wuhan-related exposure, remained an independent prognostic factor (HR (95%) 1.05 (1.01–1.08)).Conclusion There were more severe cases and poorer outcomes for COVID-19 patients treated in Hubei, which might be attributed to the prolonged duration of symptom onset to hospitalisation in the epicentre. Future studies to determine the reason for delaying hospitalisation are warranted.This study highlights the necessity of urgent and vigorous support of healthcare resources and increased public awareness during the early stages of an outbreak of COVID-19 or similar diseases https://bit.ly/39OWFf0 ER -