PT - JOURNAL ARTICLE AU - Chalmers, James D. AU - Laska, Irena F. AU - Franssen, Frits M.E. AU - Janssens, Wim AU - Pavord, Ian AU - Rigau, David AU - McDonnell, Melissa J. AU - Roche, Nicolas AU - Sin, Don D. AU - Stolz, Daiana AU - Suissa, Samy AU - Wedzicha, Jadwiga AU - Miravitlles, Marc TI - COPD吸入性皮质激素的停用:a欧188bet官网地址洲呼吸学会指南AID - 10.1183/13993003.00351-2020 DP -2020年6月01日TA -欧洲呼吸杂志PG - 2000351 VI - 55 IP - 6 4099 - //www.qdcxjkg.com/content/55/6/2000351.short 4100 - //www.qdcxjkg.com/content/55/6/2000351.full SO - Eur Respir J2020 01年6月;55 AB -吸入性皮质类固醇(ICS)联合支气管扩张剂可降低部分慢性阻塞性肺病(COPD)患者病情加重的频率。然而,有证据表明,ICS经常用于其益处尚未确定的患者。因此,有必要对COPD患者使用ICS采取个性化的方法,并考虑在没有明确适应症的患者中停用ICS。本文件报告了欧洲呼吸学会关于COPD患者停用188bet官网地址ICS的建议。我们进行了全面的证据综合,以总结与以下问题相关的所有可用证据:COPD患者是否应该停用ICS ?使用GRADE(建议、评估、发展和评价的分级)方法对证据进行评价,并在证据概要中总结结果。一个具有COPD专业知识和指南方法的委员会对证据综合进行了讨论并提出了建议。在考虑了可取和不可取的后果、证据质量以及干预措施的可行性和可接受性之间的平衡之后,指南小组做出了以下决定: 1) conditional recommendation for the withdrawal of ICS in patients with COPD without a history of frequent exacerbations, 2) strong recommendation not to withdraw ICS in patients with blood eosinophil counts ≥300 eosinophils·µL−1 and 3) strong recommendation to treat with one or two long-acting bronchodilators if ICS are withdrawn.A conditional recommendation indicates that there was uncertainty about the balance of desirable and undesirable consequences of the intervention, and that well-informed patients may make different choices regarding whether to have or not have the specific intervention.This ERS short guideline summarises the evidence and provides recommendations for ICS withdrawal in patients with COPD https://bit.ly/33R3M5w